Last reviewed · How we verify
NCT03570333
Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites
NA trial testing progenitor potential of Gingival Mesenchymal cells in Gingival Recession in 7 participants. Completed in 6 December 2025.
30 December 2019
Quick facts
| Lead sponsor | University of Alabama at Birmingham |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 7 |
| Start date | 17 September 2018 |
| Primary completion | 30 December 2019 |
| Estimated completion | 6 December 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- progenitor potential of Gingival Mesenchymal cells
Conditions studied
- Gingival Recession — all drugs for Gingival Recession →
- Lack of Keratinized Gingiva (Disorder) — all drugs for Lack of Keratinized Gingiva (Disorder) →
Sponsor
University of Alabama at Birmingham
Who can join
Adults 18 to 70, any sex, with Gingival Recession or Lack of Keratinized Gingiva (Disorder). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary purpose of this protocol is to isolate, investigate and compare the regenerative and differentiation potential of mesenchymal stem cells (MSC's) in the gingival (gum) tissue harvested from two different locations from the roof of the mouth (palate), that is from the front part(premolar)and back part(molar). MSC's are known for their capacity to form different kinds of hard and soft tissue including bone, fibers for periodontal ligaments, cementum and dentin, thus this study can help in optimizing their clinical application and transplantation approaches in tissue regeneration.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Gingival mesenchymal stem cells: Biological properties and therapeutic applications.
Peng Y, Jaar J, Tran SD. · · 2024 · cited 15× · PMID 39108352 · DOI 10.1016/j.jobcr.2024.07.003 -
Mesenchymal Stromal Cells Derived from Dental Tissues: Immunomodulatory Properties and Clinical Potential.
Poblano-Pérez LI, Castro-Manrreza ME, González-Alva P, Fajardo-Orduña GR, et al · · 2024 · cited 13× · PMID 38396665 · DOI 10.3390/ijms25041986 -
Stemness Potency of Human Gingival Cells-Application in Anticancer Therapies and Clinical Trials.
Stefańska K, Mehr K, Wieczorkiewicz M, Kulus M, et al · · 2020 · cited 12× · PMID 32824702 · DOI 10.3390/cells9081916 -
Maxillofacial-Derived Mesenchymal Stem Cells: Characteristics and Progress in Tissue Regeneration.
Yan X, Yan F, Mohammed HAG, Liu O. · · 2021 · cited 11× · PMID 34426741 · DOI 10.1155/2021/5516521 -
Gingival Mesenchymal Stem Cells: A Periodontal Regenerative Substitute.
Shetty SS, Sowmya S, Pradeep A, Jayakumar R. · · 2025 · cited 5× · PMID 39607668 · DOI 10.1007/s13770-024-00676-8 -
Current Perspectives on Mesenchymal Stem Cells as a Potential Treatment for Periodontal Diseases and Conditions.
Cai S, Li C, Wei B, Ye Z, et al · · 2025 · cited 2× · PMID 40838652 · DOI 10.1002/dvg.70024
Verify or expand the search:
- PubMed search for NCT03570333
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Gingival Recession
Currently open trials in the same condition.
- NCT07513792 — The Impact of a 3D Imaging Tool on Reducing Gum Recession During Orthodontic Treatment With Aligners · NA · recruiting
- NCT07437417 — A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth · NA · recruiting
- NCT07158541 — Comparing TCAF and MTUN With Soft Tissue Grafting for Treating Single Recessions in the Premandible · NA · recruiting
- NCT07104019 — Biofiller and Gingival Phenotype Thickening · NA · recruiting
- NCT07291583 — Hyaluronic Acid With Connective Tissue Grafting for Gingival Recession · NA · active not recruiting
Other University of Alabama at Birmingham trials
Trials by the same sponsor.
- NCT04922229 — Comparative Effectiveness in the Management of Irreversible Pulpitis · NA · not yet recruiting
- NCT05060380 — Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis · NA · withdrawn
- NCT04768777 — Behavioral Intervention for Physical Activity and Sexual Dysfunction in Multiple Sclerosis · NA · not yet recruiting
- NCT06320951 — VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine · Phase 2 · not yet recruiting
- NCT07564934 — Leveraging Extended Reality Exergaming and Telehealth to Improve Physical Activity and Health in Children With Disabilit · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03570333 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Alabama at Birmingham
- Last refreshed: 19 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03570333.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing