Who is sponsoring NCT03561675?

NCT03561675 is sponsored by University of Zurich.

What drugs are being tested in NCT03561675?

Interventions in NCT03561675: ACETAZOLAMIDE oral capsule, Placebo oral capsule.

What condition does NCT03561675 study?

NCT03561675 studies Acute Mountain Sickness.

Is NCT03561675 still recruiting?

NCT03561675 is currently completed. Last updated 13 May 2021.

Last reviewed 2021-05-13 · How we verify

NCT03561675

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years

Completed Phase 4 Last updated 13 May 2021

What this trial tests

Phase 4 trial testing ACETAZOLAMIDE oral capsule in Acute Mountain Sickness in 349 participants. Completed in 31 August 2019.

Timeline

15 May 2018

Primary endpoint
31 August 2019

31 August 2019

Quick facts

Lead sponsor	University of Zurich
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	349
Start date	15 May 2018
Primary completion	31 August 2019
Estimated completion	31 August 2019
Sites	1 location across Kyrgyzstan

Drugs / interventions tested

ACETAZOLAMIDE oral capsule — full drug profile →
Placebo oral capsule

Conditions studied

Acute Mountain Sickness — all drugs for Acute Mountain Sickness →

Sponsor

University of Zurich

Who can join

Adults 40 to 75, any sex, with Acute Mountain Sickness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Randomized, placebo controlled trial evaluating efficacy of acetazolamide in preventing acute mountain sickness in lowlanders older than 40 years travelling from 760 m to 3'100 m.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Acetazolamide to Prevent Adverse Altitude Effects in COPD and Healthy Adults.
Furian M, Mademilov M, Buergin A, Scheiwiller PM, et al · · 2022 · cited 30× · PMID 38296630 · DOI 10.1056/evidoa2100006
Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions.
Molano Franco D, Nieto Estrada VH, Gonzalez Garay AG, Martí-Carvajal AJ, et al · · 2019 · cited 15× · PMID 31012483 · DOI 10.1002/14651858.cd013315
Effect of altitude and acetazolamide on sleep and nocturnal breathing in healthy lowlanders 40 y of age or older. Data from a randomized trial.
Graf LC, Furian M, Bitos K, Mademilov M, et al · · 2023 · cited 9× · PMID 36356042 · DOI 10.1093/sleep/zsac269

Verify or expand the search:

Other trials of ACETAZOLAMIDE oral capsule

Trials testing the same drug.

NCT07517068 — The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude · EARLY_PHASE1 · active not recruiting
NCT03540914 — Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude. · Phase 4 · unknown
NCT03537924 — Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude · Phase 4 · unknown
NCT03539367 — Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude · Phase 4 · unknown
NCT03540901 — Effect of Acetazolamide on Lung Water Content by Ultrasound in Patients With Respiratory Disease at Altitude · Phase 4 · completed

Other recruiting trials for Acute Mountain Sickness

Currently open trials in the same condition.

NCT07126834 — Voluntary Isocapnic Hyperpnea in Hypoxia to Mitigate Acute Mountain Sickness · NA · active not recruiting
NCT06499714 — HighCycle Study: Effect of High Altitude on Acute Mountain Sickness in Women Related to Their Menstrual Cycle Phase · recruiting

Other University of Zurich trials

Trials by the same sponsor.

NCT07485699 — Soy Processing and Food Allergy · NA · not yet recruiting
NCT07516912 — Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland · not yet recruiting
NCT07473115 — Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustm · not yet recruiting
NCT07524023 — Emotional-distress-based Integrated Care Programme in Patients With Stable COPD · NA · recruiting
NCT06481982 — Value of Advanced MRI Techniques in the Assessment of Endometriosis · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03561675 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Zurich
Last refreshed: 13 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03561675.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing