NCT03555669

Project SOAR-Mental Health Malawi: Depression and HIV Integration

Completed NA Last updated 31 May 2023

What this trial tests

NA trial testing Depression Treatment in Depression in 2,082 participants. Completed in 31 May 2019.

Timeline

24 April 2017

Primary endpoint
31 May 2019

31 May 2019

Quick facts

Lead sponsor	University of North Carolina, Chapel Hill
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	health services research
Enrollment	2,082
Start date	24 April 2017
Primary completion	31 May 2019
Estimated completion	31 May 2019
Sites	2 locations across Malawi

Drugs / interventions tested

• Depression Treatment

Conditions studied

• Depression — all drugs for Depression →
• HIV/AIDS — all drugs for HIV/AIDS →

Sponsor

University of North Carolina, Chapel Hill

Who can join

18 and older, any sex, with Depression or HIV/AIDS. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Depression is highly prevalent among people living with HIV (PLHIV) in Malawi and elsewhere in sub-Saharan Africa (SSA). Besides its high prevalence, depression likely represents an important barrier to consistent HIV care engagement and long-term viral suppression. However, the potential for depression treatment to improve HIV care outcomes has received little attention in the region, in part because of limited mental health infrastructure. In this study, the investigators will evaluate the impact of a depression treatment program integrated within existing HIV clinics on depression response, retention in HIV care, and viral suppression. It is expected that this evaluation will yield important evidence on the impact of depression treatment integrated with HIV care for improving HIV care and mental health outcomes in Malawi.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Integrating depression management into HIV primary care in central Malawi: the implementation of a pilot capacity building program.
   Udedi M, Stockton MA, Kulisewa K, Hosseinipour MC, et al · · 2018 · cited 50× · PMID 30064418 · DOI 10.1186/s12913-018-3388-z
2. The effectiveness of depression management for improving HIV care outcomes in Malawi: protocol for a quasi-experimental study.
   Udedi M, Stockton MA, Kulisewa K, Hosseinipour MC, et al · · 2019 · cited 15× · PMID 31242877 · DOI 10.1186/s12889-019-7132-3
3. The acceptability of antidepressant treatment in people living with HIV in Malawi: A patient perspective.
   Kulisewa K, Minnick CE, Stockton MA, Gaynes BN, et al · · 2023 · cited 1× · PMID 37088107 · DOI 10.1080/17441692.2023.2201327