NCT03553693: RAPID-VL

Rapid HIV Viral Load Monitoring in High Risk Patients In Uganda

Completed NA Last updated 30 March 2021

What this trial tests

NA trial testing RAPID-VL study intervention in HIV in 2,443 participants. Completed in 16 November 2020.

Timeline

16 July 2018

Primary endpoint
16 November 2020

16 November 2020

Quick facts

Lead sponsor	University of California, San Francisco
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	health services research
Enrollment	2,443
Start date	16 July 2018
Primary completion	16 November 2020
Estimated completion	16 November 2020
Sites	1 location across Uganda

Drugs / interventions tested

• RAPID-VL study intervention

Conditions studied

• HIV — all drugs for HIV →

Sponsor

University of California, San Francisco

Who can join

2 and older, any sex, with HIV. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The RAPID-VL study will take place in 20 HIV care health facilities in Southwestern Uganda. The study will test the hypothesis that a multi-component intervention package that targets barriers to efficient and timely HIV viral load (VL) testing will improve test ordering, speed up result turnaround times, and improve the quality of VL results counseling to patients. Phase 1 of the study will consist of a 1-year retrospective medical record review in all participating health facilities. In Phase 2 the intervention will be introduced in 10 randomly chosen health facilities, while the remaining 10 sites will continue with standard VL testing and counseling operations. The study will measure the speed and efficiency of VL testing, experiences of patients and clinicians with the intervention, and the cost of the intervention.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Point-of-Care HIV Viral Load Testing: an Essential Tool for a Sustainable Global HIV/AIDS Response.
   Drain PK, Dorward J, Bender A, Lillis L, et al · · 2019 · cited 103× · PMID 31092508 · DOI 10.1128/cmr.00097-18
2. Point-of-care HIV viral load testing combined with task shifting to improve treatment outcomes (STREAM): findings from an open-label, non-inferiority, randomised controlled trial.
   Drain PK, Dorward J, Violette LR, Quame-Amaglo J, et al · · 2020 · cited 91× · PMID 32105625 · DOI 10.1016/s2352-3018(19)30402-3
3. Point-of-care viral load tests to detect high HIV viral load in people living with HIV/AIDS attending health facilities.
   Ochodo EA, Olwanda EE, Deeks JJ, Mallett S. · · 2022 · cited 18× · PMID 35266555 · DOI 10.1002/14651858.cd013208.pub2