Last reviewed · How we verify
NCT03550196: CABRIOLET
Coronary Revascularisation by rePOT
trial testing Provisional stenting with rePOT technique in Coronary Disease in 500 participants. Completed in 23 June 2022.
23 June 2022
Quick facts
| Lead sponsor | Hospices Civils de Lyon |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 500 |
| Start date | 14 May 2018 |
| Primary completion | 23 June 2022 |
| Estimated completion | 23 June 2022 |
| Sites | 4 locations across France |
Drugs / interventions tested
- Provisional stenting with rePOT technique
Conditions studied
- Coronary Disease — all drugs for Coronary Disease →
Sponsor
Hospices Civils de Lyon — full company profile →
Who can join
18 and older, any sex, with Coronary Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The presence of a coronary bifurcation complicates percutaneous revascularization. Bifurcation stenting needs to take into account the difference of diameter between proximal and distal vessels and the necessity to limit the side branch obstruction. Provisional stenting techniques with balloon juxtaposition as Kissing Balloon Inflation (KBI) fail to demonstrate a clinical benefits. This is probably explain by the detrimental effect during these technics on the proximal segment with an arterial overstretch. A new sequential technique, named rePOT, demonstrated experimentally a mechanical superiority compared to juxtaposition balloon techniques included KBI. RePOT associates an initial proximal optimizing technique (POT), a side branch inflation and a final POT. A first clinical study (n=106 patients) confirmed these excellent mechanical results with serial OCT analysis and demonstrated an excellent short term safety. Since 2017, rePOT is recommended in Europe in clinical practice. This large registry is dedicated to confirm the clinical benefits at long term after bifurcation revascularization with rePOT technique before a large randomise trial.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
One year results of coronary bifurcation revascularization with the re-POT provisional sequential technique. The CABRIOLET registry.
Dérimay F, Aminian A, Lattuca B, Souteyrand G, et al · · 2024 · cited 2× · PMID 38048882 · DOI 10.1016/j.ijcard.2023.131632
Verify or expand the search:
- PubMed search for NCT03550196
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Hospices Civils de Lyon trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03550196 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospices Civils de Lyon
- Last refreshed: 11 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03550196.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing