NCT03545750 (RRAM) is a clinical trial in Critical Illness, sponsored by Intensive Care National Audit & Research Centre.

Who is sponsoring NCT03545750?

NCT03545750 is sponsored by Intensive Care National Audit & Research Centre.

What condition does NCT03545750 study?

NCT03545750 studies Critical Illness.

Is NCT03545750 still recruiting?

NCT03545750 is currently status unknown. Last updated 25 November 2019.

Last reviewed 2019-11-25 · How we verify

NCT03545750: RRAM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Renal Replacement Anticoagulant Management

Status unknown Last updated 25 November 2019

What this trial tests

trial in Critical Illness in 85,000 participants. Status unknown.

Timeline

1 April 2018

Primary endpoint
31 December 2019

31 December 2019

Quick facts

Lead sponsor	Intensive Care National Audit & Research Centre
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	85,000
Start date	1 April 2018
Primary completion	31 December 2019
Estimated completion	31 December 2019
Sites	1 location across United Kingdom

Conditions studied

Critical Illness — all drugs for Critical Illness →

Sponsor

Intensive Care National Audit & Research Centre

Who can join

16 and older, any sex, with Critical Illness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Observational comparative effectiveness study of individual patient data using interrupted time series analysis techniques of linked data sources to establish clinical and health economic effects of moving from systemic heparin anticoagulation to regional citrate anticoagulation during continuous renal replacement therapy (CRRT) for patients treated on non-specialist Intensive Care Units (ICUs) in England and Wales.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Heparin versus citrate anticoagulation for continuous renal replacement therapy in intensive care: the RRAM observational study.
Gould DW, Doidge J, Sadique MZ, Borthwick M, et al · · 2022 · cited 7× · PMID 35212260 · DOI 10.3310/zxhi9396
Regional citrate anticoagulation versus systemic heparin anticoagulation for continuous kidney replacement therapy in intensive care.
Doidge JC, Gould DW, Sadique Z, Borthwick M, et al · · 2023 · cited 5× · PMID 36494257 · DOI 10.1016/j.jcrc.2022.154218
Renal replacement anticoagulant management: Protocol and analysis plan for an observational comparative effectiveness study of linked data sources.
Gould DW, Doidge J, Zia Sadique M, Borthwick M, et al · · 2022 · cited 4× · PMID 36033243 · DOI 10.1177/1751143720913417

Verify or expand the search:

Other recruiting trials for Critical Illness

Currently open trials in the same condition.

NCT06189924 — Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients · recruiting
NCT07418242 — Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients · recruiting
NCT07101640 — PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysp · Phase 1, PHASE2 · recruiting
NCT07177183 — Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure · NA · recruiting
NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting

Other Intensive Care National Audit & Research Centre trials

Trials by the same sponsor.

NCT05481515 — Exploring Pulse OXimeter Accuracy Across SKin Tones · completed
NCT02454257 — Risk Modelling for Quality Improvement in the Critically Ill: Making Best Use of Routinely Available Data · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03545750 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Intensive Care National Audit & Research Centre
Last refreshed: 25 November 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03545750.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing