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NCT03534674
Vitamin D3 Supplementation for AlloHSCT-RCT
NA trial testing vitamin D3 in Vitamin D Deficiency in 84 participants. Status unknown.
15 June 2019
Quick facts
| Lead sponsor | University of British Columbia |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 84 |
| Start date | 15 June 2018 |
| Primary completion | 15 June 2019 |
| Estimated completion | 15 December 2019 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- vitamin D3 (cholecalciferol) — full drug profile →
Conditions studied
- Vitamin D Deficiency — all drugs for Vitamin D Deficiency →
Sponsor
University of British Columbia
Who can join
18 and older, any sex, with Vitamin D Deficiency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is to assess whether a single oral loading dose of 100,000 IU vitamin D3 prior to allogeneic hematopoietic stem cell transplant (aHSCT) can achieve optimal 25 hydroxy-vitamin D3(25-OH-D3) levels (\>75nmol/L) at one month post aHSCT, and maintain adequate levels for at least three months, compared to our standard practice of 2000 IU vitamin D3 daily. 25-OH-D3 levels will be measured prior to vitamin D3 supplementation, and 30 as well as 100 days post vitamin D supplementation. We hypothesize that the intervention will prevent vitamin D insufficiency or deficiency in aHSCT recipients, therefore benefit aHSCT-associated morbidity, including osteoporosis.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Applications of gut microbiota in patients with hematopoietic stem-cell transplantation.
Yu J, Sun H, Cao W, Han L, et al · · 2020 · cited 19× · PMID 33292670 · DOI 10.1186/s40164-020-00194-y -
Loading dose vitamin D3 improves vitamin D insufficiency in adults undergoing hematopoietic stem cell transplantation: A randomized controlled trial.
Bai N, Lee K, Limvorapitak W, Liu E, et al · · 2023 · PMID 37883450 · DOI 10.1371/journal.pone.0284644
Verify or expand the search:
- PubMed search for NCT03534674
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT05073029 — Open Label Randomized Clinical Study to Promote a Healthy Lifestyle in Medical Students · NA · completed
- NCT03463642 — The Efficacy of Different Vitamin D Supplementation Delivery Methods · NA · completed
Other recruiting trials for Vitamin D Deficiency
Currently open trials in the same condition.
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- NCT07006714 — Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA) · Phase 4 · active not recruiting
- NCT07200011 — Effect of Vitamin D on the Clinical and Radiographic of Unsplinted Mandibular Implant Overdentures · active not recruiting
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03534674 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of British Columbia
- Last refreshed: 23 May 2018
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