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NCT03534674

Vitamin D3 Supplementation for AlloHSCT-RCT

Status unknown NA Last updated 23 May 2018
What this trial tests

NA trial testing vitamin D3 in Vitamin D Deficiency in 84 participants. Status unknown.

Timeline
15 June 2018
Primary endpoint
15 June 2019
15 December 2019

Quick facts

Lead sponsorUniversity of British Columbia
PhaseNA
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposeprevention
Enrollment84
Start date15 June 2018
Primary completion15 June 2019
Estimated completion15 December 2019
Sites1 location across Canada

Drugs / interventions tested

Conditions studied

Sponsor

University of British Columbia

Who can join

18 and older, any sex, with Vitamin D Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is to assess whether a single oral loading dose of 100,000 IU vitamin D3 prior to allogeneic hematopoietic stem cell transplant (aHSCT) can achieve optimal 25 hydroxy-vitamin D3(25-OH-D3) levels (\>75nmol/L) at one month post aHSCT, and maintain adequate levels for at least three months, compared to our standard practice of 2000 IU vitamin D3 daily. 25-OH-D3 levels will be measured prior to vitamin D3 supplementation, and 30 as well as 100 days post vitamin D supplementation. We hypothesize that the intervention will prevent vitamin D insufficiency or deficiency in aHSCT recipients, therefore benefit aHSCT-associated morbidity, including osteoporosis.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Applications of gut microbiota in patients with hematopoietic stem-cell transplantation.
    Yu J, Sun H, Cao W, Han L, et al · · 2020 · cited 19× · PMID 33292670 · DOI 10.1186/s40164-020-00194-y
  2. Loading dose vitamin D3 improves vitamin D insufficiency in adults undergoing hematopoietic stem cell transplantation: A randomized controlled trial.
    Bai N, Lee K, Limvorapitak W, Liu E, et al · · 2023 · PMID 37883450 · DOI 10.1371/journal.pone.0284644

Verify or expand the search:

Other trials of vitamin D3

Trials testing the same drug.

Other recruiting trials for Vitamin D Deficiency

Currently open trials in the same condition.

Other University of British Columbia trials

Trials by the same sponsor.

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