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NCT03530735
Finger-prick Autologous Blood (FAB) for Use in Dry Mouth
NA trial testing Finger-prick Autologous Blood (FAB) in Xerostomia in 20 participants. Status unknown.
1 December 2019
Quick facts
| Lead sponsor | Bedford Hospital NHS Trust |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 1 September 2018 |
| Primary completion | 1 December 2019 |
| Estimated completion | 1 December 2019 |
Drugs / interventions tested
- Finger-prick Autologous Blood (FAB)
Conditions studied
- Xerostomia — all drugs for Xerostomia →
- Xerostomia Due to Radiotherapy — all drugs for Xerostomia Due to Radiotherapy →
- Xerostomia Due to Hyposecretion of Salivary Gland — all drugs for Xerostomia Due to Hyposecretion of Salivary Gland →
Sponsor
Bedford Hospital NHS Trust
Who can join
18 and older, any sex, with Xerostomia or Xerostomia Due to Radiotherapy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a feasibility study that will assess the efficacy of using autologous blood to treat moderate to severe dry mouth. Dry mouth has been estimated to affect up to 64.8% of the general population (Navazesh et al., 2009) and many patients that are affected by Sjögren's syndrome or have had radiation therapy to combat head or neck cancer (Navazesh et al., 2009). The blood will be applied to the interior of the mouth by means of a mouthwash. This research poses the first potential curative treatment for dry mouth - all other current dry mouth treatments are either symptomatic or lifestyle-based. Autologous blood has been shown to be effective in treating the epithelial surface of dry eyes. This has been attributed to the analogous growth factors in the blood to that of tears - and potentially in this case, saliva - in healing the oral epithelial surface (Herbst et al., 2004).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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- PubMed search for NCT03530735
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Related trials
Other recruiting trials for Xerostomia
Currently open trials in the same condition.
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- NCT06365047 — Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine · Phase 3 · active not recruiting
- NCT06194123 — Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis · NA · active not recruiting
- NCT06287294 — An Investigation Into Taste Problems Associated With Xerostomia in Patients With Advanced Cancer · recruiting
Other Bedford Hospital NHS Trust trials
Trials by the same sponsor.
- NCT03500809 — Aqueous Release to Treat IOP Spikes Post-cataract Surgery · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03530735 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Bedford Hospital NHS Trust
- Last refreshed: 27 July 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03530735.
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