NCT03527368 (TRIM) is a NA clinical trial of Time-restricted feeding in PreDiabetes, sponsored by Johns Hopkins University.

Who is sponsoring NCT03527368?

NCT03527368 is sponsored by Johns Hopkins University.

What drugs are being tested in NCT03527368?

Interventions in NCT03527368: Time-restricted feeding, Usual feeding pattern.

What condition does NCT03527368 study?

NCT03527368 studies PreDiabetes, Obesity.

Is NCT03527368 still recruiting?

NCT03527368 is currently completed. Last updated 17 May 2021.

Last reviewed 2021-05-17 · How we verify

NCT03527368: TRIM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Time-Restricted Intake of Meals Study

Completed NA Last updated 17 May 2021

What this trial tests

NA trial testing Time-restricted feeding in PreDiabetes in 41 participants. Completed in 31 December 2019.

Timeline

24 September 2018

Primary endpoint
23 December 2019

31 December 2019

Quick facts

Lead sponsor	Johns Hopkins University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	41
Start date	24 September 2018
Primary completion	23 December 2019
Estimated completion	31 December 2019
Sites	1 location across United States

Drugs / interventions tested

Time-restricted feeding
Usual feeding pattern

Conditions studied

PreDiabetes — all drugs for PreDiabetes →
Obesity — all drugs for Obesity →

Sponsor

Johns Hopkins University

Who can join

Adults 21 to 69, any sex, with PreDiabetes or Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

TRIM is a randomized, controlled feeding study to evaluate if eating earlier in the day vs. later in the day impacts weight and glucose homeostasis.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Intermittent fasting for the prevention of cardiovascular disease.
Allaf M, Elghazaly H, Mohamed OG, Fareen MFK, et al · · 2021 · cited 66× · PMID 33512717 · DOI 10.1002/14651858.cd013496.pub2
Effect of Isocaloric, Time-Restricted Eating on Body Weight in Adults With Obesity : A Randomized Controlled Trial.
Maruthur NM, Pilla SJ, White K, Wu B, et al · · 2024 · cited 18× · PMID 38639542 · DOI 10.7326/m23-3132
Design and Implementation of a Time-Restricted Eating Intervention in a Randomized, Controlled Eating Study.
White K, Wu B, Pilla SJ, Charleston J, et al · · 2023 · cited 3× · PMID 37111198 · DOI 10.3390/nu15081978
Effects of time-restricted eating on actigraphy-derived sleep parameters: post hoc analysis of a randomized, isocaloric feeding study.
Duan D, Pham LV, Jun JC, Turkson-Ocran RA, et al · · 2025 · PMID 40241264 · DOI 10.1093/sleep/zsaf089

Verify or expand the search:

Other trials of Time-restricted feeding

Trials testing the same drug.

NCT07207044 — FAXAGE: Fasting And Exercise To Slow Aging In Humans · NA · recruiting
NCT04966351 — Countermeasures to Circadian Misalignment · NA · recruiting

Other recruiting trials for PreDiabetes

Currently open trials in the same condition.

NCT06897982 — Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center · NA · recruiting
NCT06967558 — The Role of Islet GLP-1 in the Pathogenesis of Prediabetes · Phase 2 · recruiting
NCT06482944 — Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes · NA · recruiting
NCT06989164 — Post Prandial Individual Responses to Different Foods · NA · recruiting
NCT07254572 — Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes · Phase 4 · recruiting

Other Johns Hopkins University trials

Trials by the same sponsor.

NCT06236542 — Tracheostomy Robotics and Cutting-edge Health Education for Airway Safety · NA · not yet recruiting
NCT07532252 — Daridorexant for Alcohol Use Disorder · Phase 2 · not yet recruiting
NCT06687655 — Impact of Exogenous Ketones on Sleep Apnea · Phase 1, PHASE2 · not yet recruiting
NCT07079111 — 3D Printed Occlusal Splints for Intraoperative Use · NA · not yet recruiting
NCT02998502 — The Use of a FDA Cleared, Drug-free, Breathing System for Anxiety and Panic Disorders in Children and Teens · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03527368 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
Last refreshed: 17 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03527368.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing