Last reviewed · How we verify
NCT03526081
Absorption, Metabolism and Excretion of Apigenin and Apigenin Glycosides
NA trial testing Chamomile Tea in Healthy in 17 participants. Completed in 30 July 2016.
30 July 2016
Quick facts
| Lead sponsor | University of California, Davis |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 17 |
| Start date | 20 January 2015 |
| Primary completion | 30 July 2016 |
| Estimated completion | 30 July 2016 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Chamomile Tea — full drug profile →
- Parsley based drink
- Parsley Yogurt
- Apigenin
- Parsley-based drink (II)
Conditions studied
- Healthy — all drugs for Healthy →
Sponsor
University of California, Davis
Who can join
Adults 25 to 60, male only, with Healthy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Probe dietary intervention study in healthy young adult males to evaluate the concentration of apigenin derived metabolites in plasma and urine after single acute intakes of different apigenin-containing test materials.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
TGF-β signaling in the tumor metabolic microenvironment and targeted therapies.
Shi X, Yang J, Deng S, Xu H, et al · · 2022 · cited 188× · PMID 36115986 · DOI 10.1186/s13045-022-01349-6 -
Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment.
Zhang J, Xu HX, Zhu JQ, Dou YX, et al · · 2023 · cited 49× · PMID 37416770 · DOI 10.7150/ijbs.82401 -
Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults.
Borges G, Fong RY, Ensunsa JL, Kimball J, et al · · 2022 · cited 24× · PMID 35452808 · DOI 10.1016/j.freeradbiomed.2022.04.007 -
Fibroblast PI3K/AKT signaling and extracellular matrix homeostasis: mechanisms, targets, and delivery challenges.
Fang C, Zeng Z, Ni B, Wen X, et al · · 2025 · PMID 41509070 · DOI 10.3389/fcell.2025.1681875
Verify or expand the search:
- PubMed search for NCT03526081
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Chamomile Tea
Trials testing the same drug.
- NCT05272475 — The Acute Effects of Chamomile Intake on Blood Coagulation Tests in Healthy Volunteers · NA · completed
- NCT05006378 — Effect of Chamomile Intake on Blood Coagulation Tests in Healthy Volunteers · NA · completed
Other recruiting trials for Healthy
Currently open trials in the same condition.
- NCT06707207 — Predicting Future Errors During Skill Performance · recruiting
- NCT07169630 — PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) · Phase 1 · recruiting
- NCT07499414 — The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease. · NA · recruiting
- NCT07496697 — Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects · NA · recruiting
- NCT06431932 — Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity · Phase 1, PHASE2 · recruiting
Other University of California, Davis trials
Trials by the same sponsor.
- NCT07024498 — Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment · NA · not yet recruiting
- NCT07322133 — Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) · Phase 4 · recruiting
- NCT07384767 — Efficacy and Safety of Topical Timolol in Secondary Intention Surgical Wounds Healing · Phase 2 · not yet recruiting
- NCT07267494 — Image-Guided Herniorrhaphy Study · NA · not yet recruiting
- NCT04614714 — Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants · Phase 2, PHASE3 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03526081 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of California, Davis
- Last refreshed: 23 May 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03526081.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing