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NCT03526081

Absorption, Metabolism and Excretion of Apigenin and Apigenin Glycosides

Completed NA Last updated 23 May 2019
What this trial tests

NA trial testing Chamomile Tea in Healthy in 17 participants. Completed in 30 July 2016.

Timeline
20 January 2015
Primary endpoint
30 July 2016
30 July 2016

Quick facts

Lead sponsorUniversity of California, Davis
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationnon randomized
Designcrossover
Maskingsingle
Primary purposebasic science
Enrollment17
Start date20 January 2015
Primary completion30 July 2016
Estimated completion30 July 2016
Sites2 locations across United States

Drugs / interventions tested

Conditions studied

Sponsor

University of California, Davis

Who can join

Adults 25 to 60, male only, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Probe dietary intervention study in healthy young adult males to evaluate the concentration of apigenin derived metabolites in plasma and urine after single acute intakes of different apigenin-containing test materials.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. TGF-β signaling in the tumor metabolic microenvironment and targeted therapies.
    Shi X, Yang J, Deng S, Xu H, et al · · 2022 · cited 188× · PMID 36115986 · DOI 10.1186/s13045-022-01349-6
  2. Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment.
    Zhang J, Xu HX, Zhu JQ, Dou YX, et al · · 2023 · cited 49× · PMID 37416770 · DOI 10.7150/ijbs.82401
  3. Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults.
    Borges G, Fong RY, Ensunsa JL, Kimball J, et al · · 2022 · cited 24× · PMID 35452808 · DOI 10.1016/j.freeradbiomed.2022.04.007
  4. Fibroblast PI3K/AKT signaling and extracellular matrix homeostasis: mechanisms, targets, and delivery challenges.
    Fang C, Zeng Z, Ni B, Wen X, et al · · 2025 · PMID 41509070 · DOI 10.3389/fcell.2025.1681875

Verify or expand the search:

Other trials of Chamomile Tea

Trials testing the same drug.

Other recruiting trials for Healthy

Currently open trials in the same condition.

Other University of California, Davis trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing