NCT03503838

A Pilot Study of Online Yoga for MPN Patients

Completed NA Last updated 25 February 2022

What this trial tests

NA trial testing Online Yoga in Quality of Life in 62 participants. Completed in 12 June 2017.

Timeline

23 September 2016

Primary endpoint
12 June 2017

12 June 2017

Quick facts

Lead sponsor	Arizona State University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	62
Start date	23 September 2016
Primary completion	12 June 2017
Estimated completion	12 June 2017

Drugs / interventions tested

• Online Yoga

Conditions studied

• Quality of Life — all drugs for Quality of Life →
• Cancer — all drugs for Cancer →

Sponsor

Arizona State University

Who can join

Eligibility, any sex, with Quality of Life or Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis (MF) are chronic Philadelphia negative myeloproliferative neoplasms (MPNs) that are characterized by clonal proliferation of hematopoietic stem cells, intramedullary fibrosis, and splenomegaly. While disease manifestations may vary amongst the spectrum of MPNs, quality of life considerations including fatigue, concentration difficulties, pain, sleep disturbance, and depression are negatively affected in most MPN patients. Inflammation has been suggested to be involved in the development of disease-related symptoms. Specific pro-inflammatory cytokines (e.g., IL-1, IL-6, IL-8, and TNF-α) have been associated with particular patient-reported symptoms, including fatigue, abdominal complaints, microvascular symptoms, and constitutional symptoms. Pharmacologic therapy can positively impact MPN related symptoms, specifically with JAK inhibition, however, these treatments often come with negative side effects (e.g., anemia, thrombocytopenia). Much opportunity remains for improving MPN symptoms (i.e., fatigue, insomnia, loss of muscle mass, and debilitation) and quality of life.

Yoga, a gentle form of meditative exercise, has been shown to improve symptom management and quality of life parameters in cancer patients and may be effective in improving MPN-related symptoms. Here we propose a study evaluating the efficacy of an online yoga intervention comparing a yoga group to a wait-list control group for improving symptom burden and quality of life in MPN patients. Secondarily, we plan to evaluate the feasibility of collecting potential biomarkers that are related to MPN disease-related activity, such as fatigue (i.e., cortisol and serum cytokines).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research.
   Huberty J, Eckert R, Dueck A, Kosiorek H, et al · · 2019 · cited 58× · PMID 31174535 · DOI 10.1186/s12906-019-2530-8