NCT03484507 is a Phase 2 clinical trial of Chlorhexidine in Acanthamoeba Keratitis, sponsored by University of California, San Francisco.

Who is sponsoring NCT03484507?

NCT03484507 is sponsored by University of California, San Francisco.

What drugs are being tested in NCT03484507?

Interventions in NCT03484507: Chlorhexidine, Povidone-Iodine, Prednisolone Sodium Phosphate, Hydroxypropyl Methylcellulose, Prednisolone Sodium Phosphate, Hydroxypropyl Methylcellulose.

What condition does NCT03484507 study?

NCT03484507 studies Acanthamoeba Keratitis.

Is NCT03484507 still recruiting?

NCT03484507 is currently completed. Last updated 6 February 2024.

Last reviewed 2024-02-06 · How we verify

NCT03484507

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Parasitic Ulcer Treatment Trial Pilot

Completed Phase 2 Last updated 6 February 2024

What this trial tests

Phase 2 trial testing Chlorhexidine in Acanthamoeba Keratitis in 49 participants. Completed in 15 November 2022.

Timeline

1 January 2018

Primary endpoint
31 December 2024

15 November 2022

Quick facts

Lead sponsor	University of California, San Francisco
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	49
Start date	1 January 2018
Primary completion	31 December 2024
Estimated completion	15 November 2022
Sites	2 locations across India

Drugs / interventions tested

Chlorhexidine (CHLORHEXIDINE) — full drug profile →
Povidone-Iodine — full drug profile →
Prednisolone Sodium Phosphate — full drug profile →
Hydroxypropyl Methylcellulose — full drug profile →
Prednisolone Sodium Phosphate — full drug profile →
Hydroxypropyl Methylcellulose — full drug profile →

Conditions studied

Acanthamoeba Keratitis — all drugs for Acanthamoeba Keratitis →

Sponsor

University of California, San Francisco

Who can join

13 and older, any sex, with Acanthamoeba Keratitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a study of optimal treatments for acanthamoeba keratitis. In the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidone iodine. After four weeks of therapy, participants will be re-randomized to early corticosteroids, later corticosteroids, or placebo.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Adjunctive povidone-iodine for <i>Acanthamoeba</i> keratitis: a randomized trial.
Rajaraman R, Kassaye I, Sharma SS, Prajna NV, et al · · 2026 · PMID 41914638 · DOI 10.1128/aac.01512-25

Verify or expand the search:

Other trials of Chlorhexidine

Trials testing the same drug.

NCT07031388 — Mouthwashes for Gingivitis: Comparing a Hydrogen Peroxide-Hyaluronic Acid Mix, Hyaluronic Acid, and Chlorhexidine, A Tri · NA · active not recruiting
NCT07058727 — Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative Pain · NA · recruiting
NCT06627270 — Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer · Phase 2 · recruiting
NCT07197073 — Antibacterial Effect of Ozonated Olive Oil, Propolis and Chlorhexidine Mouthwashes in Pediatric Patients · NA · completed
NCT06667089 — Povidone-Iodine Versus Chlorhexidine in Surgical Wound Care · NA · completed

Other recruiting trials for Acanthamoeba Keratitis

Currently open trials in the same condition.

NCT07195864 — Retrospective Chart Review of Patients With Acanthamoeba Keratitis Who Have Received 0.8 mg/mL Polihexanide as Part of t · recruiting

Other University of California, San Francisco trials

Trials by the same sponsor.

NCT05284773 — Screening for Acute Malnutrition · NA · withdrawn
NCT04634851 — Video Home Visits for Dietary Counselling · NA · not yet recruiting
NCT06065670 — Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a M · Phase 1, PHASE2 · not yet recruiting
NCT07534098 — Intervention for Hearing Health Among Native Americans · NA · not yet recruiting
NCT06960421 — Exercise-based Frailty Intervention in Lung Transplantation (XFIT) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03484507 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, San Francisco
Last refreshed: 6 February 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03484507.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing