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NCT03483909: GestTMS
Transcranial Magnetic Stimulation to Improve Gesture Control
Phase 1, PHASE2 trial testing left IFG iTBS in Schizophrenia and Related Disorders in 40 participants. Completed in 23 April 2019.
1 April 2019
Quick facts
| Lead sponsor | University of Bern |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 29 January 2018 |
| Primary completion | 1 April 2019 |
| Estimated completion | 23 April 2019 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- left IFG iTBS
- right IPL cTBS
- Placebo
Conditions studied
- Schizophrenia and Related Disorders — all drugs for Schizophrenia and Related Disorders →
Sponsor
University of Bern
Who can join
Adults 18 to 65, any sex, with Schizophrenia and Related Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The majority of schizophrenia patients is impaired in hand gesture performance, which contributes to poor functional outcome and poor communication skills. The left inferior frontal gyrus (IFG) and the left inferior parietal lobe (IPL) are key nodes of the gesture network, which is less active in patients with schizophrenia. Here, the investigators test single sessions of rTMS/TBS known to either enhance or inhibit local brain activity for app. 1 hour. The investigators aim to determine, which protocol may improve gesture performance in patients and healthy controls. This is a randomized, double-blind, cross-over, placebo-controlled single-center trial in 20 patients with schizophrenia spectrum disorders and 20 healthy controls. Gesture performance will be tested immediately after each TMS session, which are separated by 48 hours. Results of this study will inform larger interventional trials comparing 2 TMS protocols with repeated administration.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Single Session Transcranial Magnetic Stimulation Ameliorates Hand Gesture Deficits in Schizophrenia.
Walther S, Kunz M, Müller M, Zürcher C, et al · · 2020 · cited 53× · PMID 31634401 · DOI 10.1093/schbul/sbz078
Verify or expand the search:
- PubMed search for NCT03483909
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03483909 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Bern
- Last refreshed: 29 April 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03483909.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing