Who is sponsoring NCT03482297?

NCT03482297 is sponsored by Vanderbilt University Medical Center.

What drugs are being tested in NCT03482297?

Interventions in NCT03482297: automated abdominal binder, Sham binder, Placebo, Midodrine.

What condition does NCT03482297 study?

NCT03482297 studies Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy.

Is NCT03482297 still recruiting?

NCT03482297 is currently recruiting now. Last updated 12 November 2025.

Last reviewed 2025-11-12 · How we verify

NCT03482297

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Automated Abdominal Binder for Orthostatic Hypotension

Recruiting now Phase 1, PHASE2 Last updated 12 November 2025

What this trial tests

Phase 1, PHASE2 trial testing automated abdominal binder in Orthostatic Hypotension in 31 participants. Currently enrolling.

Timeline

1 March 2018

Primary endpoint
1 July 2026

1 December 2026

Quick facts

Lead sponsor	Vanderbilt University Medical Center
Phase	Phase 1, PHASE2
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	31
Start date	1 March 2018
Primary completion	1 July 2026
Estimated completion	1 December 2026
Sites	1 location across United States

Drugs / interventions tested

automated abdominal binder
Sham binder
Placebo
Midodrine — full drug profile →

Conditions studied

Orthostatic Hypotension — all drugs for Orthostatic Hypotension →
Autonomic Failure — all drugs for Autonomic Failure →
Pure Autonomic Failure — all drugs for Pure Autonomic Failure →
Multiple System Atrophy — all drugs for Multiple System Atrophy →

Sponsor

Vanderbilt University Medical Center

Who can join

Adults 40 to 80, any sex, with Orthostatic Hypotension or Autonomic Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure. The purpose of this study is to determine safety and effectiveness of the automated abdominal binder in improving orthostatic tolerance in these patients.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Symptomatic Care in Multiple System Atrophy: State of the Art.
Grossauer A, Sidoroff V, Heim B, Seppi K. · · 2023 · cited 11× · PMID 35581488 · DOI 10.1007/s12311-022-01411-6

Verify or expand the search:

Other recruiting trials for Orthostatic Hypotension

Currently open trials in the same condition.

NCT06714565 — The Value of Near-infrared Spectroscopy and Blood Pressure Measurements in Estimating Future Fall Risk in Older Adults · recruiting
NCT07196397 — POLish Registry of CArdioneuroablation and CArdioneuromodulation · recruiting
NCT06439498 — Frequency of Orthostatic Hypotension in Patients Who Underwent Colonoscopy · active not recruiting
NCT05960448 — Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury · NA · recruiting
NCT05725499 — The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI) · NA · recruiting

Other Vanderbilt University Medical Center trials

Trials by the same sponsor.

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NCT07431541 — Topical Carboxytherapy Paste Following Microneedling · Phase 1, PHASE2 · not yet recruiting
NCT07224711 — The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03482297 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
Last refreshed: 12 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03482297.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing