NCT03480555 (Replenish) is a NA clinical trial of Replenish Protein in Critical Illness, sponsored by King Abdullah International Medical Research Center.

Who is sponsoring NCT03480555?

NCT03480555 is sponsored by King Abdullah International Medical Research Center.

What drugs are being tested in NCT03480555?

Interventions in NCT03480555: Replenish Protein, Standard protein.

What condition does NCT03480555 study?

NCT03480555 studies Critical Illness, ARDS, Septic Shock, Multiple Trauma, Seizure Disorder, Hemorrhagic Shock.

Is NCT03480555 still recruiting?

NCT03480555 is currently completed. Last updated 5 January 2021.

Last reviewed 2021-01-05 · How we verify

NCT03480555: Replenish

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients

Completed NA Last updated 5 January 2021

What this trial tests

NA trial testing Replenish Protein in Critical Illness in 40 participants. Completed in 10 September 2019.

Timeline

16 May 2018

Primary endpoint
10 May 2019

10 September 2019

Quick facts

Lead sponsor	King Abdullah International Medical Research Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	40
Start date	16 May 2018
Primary completion	10 May 2019
Estimated completion	10 September 2019
Sites	2 locations across Saudi Arabia

Drugs / interventions tested

Replenish Protein
Standard protein

Conditions studied

Critical Illness — all drugs for Critical Illness →
ARDS — all drugs for ARDS →
Septic Shock — all drugs for Septic Shock →
Multiple Trauma — all drugs for Multiple Trauma →

Sponsor

King Abdullah International Medical Research Center — full company profile →

Who can join

18 and older, any sex, with Critical Illness or ARDS. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this study, we will explore the feasibility of a randomized controlled trial that will compare high protein dose from ICU day 6 to 14 with moderate protein intake.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Replacing protein via enteral nutrition in a stepwise approach in critically ill patients: A pilot randomized controlled trial (REPLENISH pilot trial).
Arabi YM, Al-Dorzi HM, Tamim H, Sadat M, et al · · 2021 · cited 10× · PMID 34330462 · DOI 10.1016/j.clnesp.2021.05.008

Verify or expand the search:

Other recruiting trials for Critical Illness

Currently open trials in the same condition.

NCT06189924 — Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients · recruiting
NCT07418242 — Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients · recruiting
NCT07101640 — PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysp · Phase 1, PHASE2 · recruiting
NCT07177183 — Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure · NA · recruiting
NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting

Other King Abdullah International Medical Research Center trials

Trials by the same sponsor.

NCT07089251 — The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery · Phase 4 · recruiting
NCT06404996 — Smart-phone Application Versus Conventional Paper for the Documentation of Voiding Dysfunction in Children · NA · not yet recruiting
NCT06595550 — The Effect of Whey Protein Consumption on Hypoglycemia in Adults with Type 1 Diabetes During Fasting Ramadan. · NA · completed
NCT06627166 — Viral Etiology of Severe Acute Respiratory InFection in CriticallY Ill Patients Registry · terminated
NCT05421468 — Timing of Thyroxine Dose In Ramadan · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03480555 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by King Abdullah International Medical Research Center
Last refreshed: 5 January 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03480555.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing