NCT03472612

OSA Recurrence in CPAP Withdrawal

Completed NA Last updated 15 March 2022

What this trial tests

NA trial testing CPAP withdrawal in OSA in 25 participants. Completed in 1 October 2019.

Timeline

9 April 2018

Primary endpoint
30 June 2019

1 October 2019

Quick facts

Lead sponsor	Guy's and St Thomas' NHS Foundation Trust
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	25
Start date	9 April 2018
Primary completion	30 June 2019
Estimated completion	1 October 2019
Sites	1 location across United Kingdom

Drugs / interventions tested

• CPAP withdrawal

Conditions studied

• OSA — all drugs for OSA →

Sponsor

Guy's and St Thomas' NHS Foundation Trust

Who can join

Adults 18 to 80, any sex, with OSA. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Continuous positive airway pressure (CPAP) therapy is the most effective Treatment for obstructive sleep apnoea (OSA ). However, adherence to CPAP is often limited. There are established and emerging treatment alternatives to CPAP available, however, they are usually less effective than CPAP. To develop novel treatment methods and to predict who will respond to which treatment, the mechanism underlying obstructive sleep apnoea and different patient types should be described. Especially the contribution of the upper airway function and central respiratory control should be studied for this purpose. In a prospective interventional study, patients with OSA effectively treated with CPAP will undergo physiologic measurements during a two week period off CPAP to define the pathophysiological mechanisms associated with OSA recurrence. This knowledge could facilitate individually tailored treatment and improve therapy adherence and patient outcomes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Educational, supportive and behavioural interventions to improve usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea.
   Askland K, Wright L, Wozniak DR, Emmanuel T, et al · · 2020 · cited 56× · PMID 32255210 · DOI 10.1002/14651858.cd007736.pub3