NCT03472118: OxALa

High Flow Oxygen in Patients Undergoing Suspension Laryngoscopy Under General Anesthesia

Terminated NA Last updated 8 April 2026

What this trial tests

NA trial testing Nasal High Flow Oxygen in Laryngoscopy in 29 participants. Terminated before completion.

Timeline

5 July 2018

Primary endpoint
24 January 2019

24 January 2019

Quick facts

Lead sponsor	CMC Ambroise Paré
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	29
Start date	5 July 2018
Primary completion	24 January 2019
Estimated completion	24 January 2019
Sites	2 locations across France

Drugs / interventions tested

• Nasal High Flow Oxygen

Conditions studied

• Laryngoscopy — all drugs for Laryngoscopy →
• Apnea — all drugs for Apnea →
• Anesthesia — all drugs for Anesthesia →

Sponsor

CMC Ambroise Paré — full company profile →

Who can join

18 and older, any sex, with Laryngoscopy or Apnea. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients undergoing suspension laryngoscopy under general anaesthesia have oxygen delivered to their lungs through different methods. Inserting a tube in the trachea is the best means for oxygen delivery. However, it does not allow for optimal visibility of the operated area. Other techniques can be used but have disadvantages with some being associated with serious complications. No consensus exists regarding the best airway management technique for this intervention.

The aim of the study is to investigate a new device that delivers oxygen at very high flow through a nasal cannula in patients undergoing suspension laryngoscopy under general anaesthesia. This technique allows the surgeon to have a perfect visualisation of the laryngeal structures while allowing the delivery of oxygen for the lungs.

After informed consent, adult patients undergoing suspension laryngoscopy under general anaesthesia in two French hospitals will receive high flow oxygen throughout the procedure. At the end of surgery or, whenever applicable, at the time of technique failure (with a decrease in blood oxygen saturation to less than 92%), blood will be drawn for analysis. All patients will have a thin security catheter inserted in their trachea (the currently used technique in both participating hospitals), allowing for rescue high frequency ventilation if ever the study technique fails.

The safety of the device will also be assessed by analysing the blood samples for signs of carbon dioxide accumulation and by collecting any intra or post-operative complications.

If the device shows to be effective at maintaining blood oxygenation without significant associated risks, it could be used for other surgical situations where airway management is expected to be difficult.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. High-flow nasal oxygen for suspension laryngoscopy: a multicenter open-label study.
   Saad M, Albi-Feldzer A, Taouachi R, Wagner I, et al · · 2022 · cited 3× · PMID 36524243 · DOI 10.1177/03000605221140685