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NCT06777355: LIFESAVE
Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery
trial testing Transthoracic and Transesophageal echography within 24 hours post cardiac surgery in Postoperative Complications in 32 participants. Completed in 4 July 2025.
4 July 2025
Quick facts
| Lead sponsor | CMC Ambroise Paré |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 32 |
| Start date | 24 February 2025 |
| Primary completion | 4 July 2025 |
| Estimated completion | 4 July 2025 |
| Sites | 1 location across France |
Drugs / interventions tested
- Transthoracic and Transesophageal echography within 24 hours post cardiac surgery
Conditions studied
- Postoperative Complications — all drugs for Postoperative Complications →
- Heart Failure — all drugs for Heart Failure →
Sponsor
CMC Ambroise Paré — full company profile →
Who can join
18 and older, any sex, with Postoperative Complications or Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess ventricular function, they have limitations in terms of accuracy. The pulmonary artery catheter remains the gold standard for assessing RVD. This dysfunction is associated with an increased risk of both renal and hepatic failure, complications that significantly affect patient outcomes. Doppler ultrasound has emerged as a valuable tool in predicting these complications, particularly in monitoring portal circulation and hepatic perfusion. This study aims to explore the association between portal flow pulsatility and RVD after cardiac surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06777355
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other CMC Ambroise Paré trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06777355 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CMC Ambroise Paré
- Last refreshed: 1 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06777355.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing