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NCT03441412
A Study of the Effect of Epinephrine on Platelet Reactivity in Subjects Treated With Ticagrelor
Phase 1 trial testing Ticagrelor 90mg in Healthy Volunteers in 10 participants. Completed in 28 March 2018.
28 March 2018
Quick facts
| Lead sponsor | Vastra Gotaland Region |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 10 |
| Start date | 28 February 2018 |
| Primary completion | 28 March 2018 |
| Estimated completion | 28 March 2018 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Ticagrelor 90mg — full drug profile →
- Epinephrine (epinephrine) — full drug profile →
- Metoprolol (metoprolol) — full drug profile →
Conditions studied
- Healthy Volunteers — all drugs for Healthy Volunteers →
Sponsor
Vastra Gotaland Region — full company profile →
Who can join
Adults 18 to 40, male only, with Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study is an experimental observational study in ten healthy volunteers. Based on an in vitro study, it is hypothesize that a low dose epinephrine infusion will improve platelet function in healthy volunteers who have received ticagrelor. Volunteers fulfilling all of the inclusion and none of the exclusion criteria will be included. Enrollment will be continued until the required sample size is achieved (10 subjects). Once informed consent is obtained, screening data will be collected to determine each subject's eligibility for study participation. The total expected duration of subject participation is 18 days, from screening visit to end of follow-up. The active participation is 8h (study procedure 4 hours, observation period 4 hours).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Adrenaline Improves Platelet Reactivity in Ticagrelor-Treated Healthy Volunteers.
Singh S, Damén T, Nygren A, Shams Hakimi C, et al · · 2019 · cited 7× · PMID 30780166 · DOI 10.1055/s-0039-1683461
Verify or expand the search:
- PubMed search for NCT03441412
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Other Vastra Gotaland Region trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03441412 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vastra Gotaland Region
- Last refreshed: 11 May 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03441412.
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