NCT03439618

Comparison of Time-restricted Feeding and Continuous Feeding in Critically Ill Patients

Status unknown NA Last updated 2 June 2020

What this trial tests

NA trial testing time-restricted feeding in Feeding Behavior in 380 participants. Status unknown.

Timeline

9 May 2018

Primary endpoint
8 May 2021

30 August 2022

Quick facts

Lead sponsor	Qingdao University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	380
Start date	9 May 2018
Primary completion	8 May 2021
Estimated completion	30 August 2022
Sites	1 location across China

Drugs / interventions tested

• time-restricted feeding
• continuous feeding

Conditions studied

• Feeding Behavior — all drugs for Feeding Behavior →

Sponsor

Qingdao University

Who can join

Eligibility, any sex, with Feeding Behavior. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In the nutrition guideline (A.S.P.E.N guideline), there was no recommendation about the feeding type in enteral feeding of critically ill patients. Continuous feeding is the most popular feeding type in ICU because of its less nursing burden and reducing the aspiration incidence theoretically. However, some previous studies demonstrated that there were no complications differences between continuous and time-restricted feedings（such as intermittent feedings）.

In ICU, the disorder of protein synthesis is a universal problem and is associated with ICU acquired weakness. Time-restricted feeding is more physical than continuous feeding. In some animal researches, time-restricted feeding was proved to have a greater stimulatory effect on protein synthesis than continuous feeding. Besides of light, time-restricted feeding can may also adjust the biological rhythms. It is known that biological clocks could affect energy metabolism, emotion and so on. Until now, there are no enough clinical studies to prove the advantages in time-restricted feeding in ICU patients.So researchers designed the study to compare the time-restricted feeding and continuous feeding effect(especially protein synthesis) on ICU patients.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Intermittent fasting for the prevention of cardiovascular disease.
   Allaf M, Elghazaly H, Mohamed OG, Fareen MFK, et al · · 2021 · cited 66× · PMID 33512717 · DOI 10.1002/14651858.cd013496.pub2
2. Comparison of sequential feeding and continuous feeding on the blood glucose of critically ill patients: a non-inferiority randomized controlled trial.
   Ren CJ, Yao B, Tuo M, Lin H, et al · · 2021 · cited 10× · PMID 34397596 · DOI 10.1097/cm9.0000000000001684