NCT04443335 is a NA clinical trial of continous feeding in Feeding Behavior, sponsored by Qingdao University.

Who is sponsoring NCT04443335?

NCT04443335 is sponsored by Qingdao University.

What drugs are being tested in NCT04443335?

Interventions in NCT04443335: continous feeding, sequential feeding.

What condition does NCT04443335 study?

NCT04443335 studies Feeding Behavior.

Is NCT04443335 still recruiting?

NCT04443335 is currently completed. Last updated 14 November 2022.

Last reviewed 2022-11-14 · How we verify

NCT04443335

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Continuous Feeding and Sequential Feeding on Gut Microbiota and Metabolomics in Critically Ill Patients

Completed NA Last updated 14 November 2022

What this trial tests

NA trial testing continous feeding in Feeding Behavior in 158 participants. Completed in 28 June 2022.

Timeline

2 July 2020

Primary endpoint
28 June 2022

28 June 2022

Quick facts

Lead sponsor	Qingdao University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	158
Start date	2 July 2020
Primary completion	28 June 2022
Estimated completion	28 June 2022
Sites	1 location across China

Drugs / interventions tested

continous feeding
sequential feeding

Conditions studied

Feeding Behavior — all drugs for Feeding Behavior →

Sponsor

Qingdao University

Who can join

18 and older, any sex, with Feeding Behavior. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Continuous feeding is the most popular enteral feeding mode in the ICU because of its lower nursing burden and theoretically better intestinal toleration. However, continuous feeding is nonphysiological. We proposed a feeding mode called sequential feeding, as it utilizes a combination of continuous feeding in the beginning, time-restricted feeding in the second stage, and oral feeding at last. The gut microbiota plays a critical role in human health due to its many useful functions. Not only dietary structure but also eating mode (eating time for example) influenced the gut microbiota in a healthy population. Therefore, we think this new feeding mode, sequential feeding, also has different influences on gut microbiota and metabolomics in critically ill patients compared to continuous feeding.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Sequential versus continuous feeding and its effect on the gut microbiota in critically ill patients: A randomized controlled trial.
Yao B, Liu JY, Liu Y, Song XX, et al · · 2025 · cited 2× · PMID 39798866 · DOI 10.1016/j.clnesp.2025.01.019

Verify or expand the search:

Other recruiting trials for Feeding Behavior

Currently open trials in the same condition.

NCT07392905 — Food Intake-Related Brain and Metabolic Responses in Obesity · NA · recruiting
NCT06486922 — Starting Early to Prevent Obesity Using Telehealth (StEP OUT): Intervention Development Trial · NA · recruiting
NCT05773157 — Evaluation of SNAP-Ed Online Modules to Improve Responsive Feeding Practices of Caregivers · NA · active not recruiting
NCT05881759 — Integrating Food Rx With Best Feeding Practices With EFNEP · NA · recruiting
NCT05916144 — The Effect of Interaction-Based Early Education Program Applied to Grandparents on the Grandchildren's Health · NA · active not recruiting

Other Qingdao University trials

Trials by the same sponsor.

NCT06359977 — The Effect of Quantitative EEG Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure · not yet recruiting
NCT06083831 — The Effect of Sequential Feeding for Circadian Rhythm and Gut Flora Rhythm in Critically Ill Patients · unknown
NCT05842993 — Study of Hydrogen Inhalation Compared With Placebo in Type 2 Diabetes Patients · NA · unknown
NCT05905588 — Study of Hydrogen-rich Water Compared With Placebo in Type 2 Diabetes Patients · NA · unknown
NCT03552601 — The Effect of Negatively Fluid Balancing Speed for ICU Patients With Acute Respiratory Distress Syndrome · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04443335 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Qingdao University
Last refreshed: 14 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04443335.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing