NCT03436914 is a NA clinical trial of PPI in Non-erosive Gatroesophageal Reflux Disease, sponsored by Yonsei University.

Who is sponsoring NCT03436914?

NCT03436914 is sponsored by Yonsei University.

What drugs are being tested in NCT03436914?

Interventions in NCT03436914: PPI.

What condition does NCT03436914 study?

NCT03436914 studies Non-erosive Gatroesophageal Reflux Disease.

Is NCT03436914 still recruiting?

NCT03436914 is currently completed. Last updated 2 January 2020.

Last reviewed 2020-01-02 · How we verify

NCT03436914

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment Response of Maintenance Dose of Proton Pump Inhibitor in Patients With Nonerosive Gatroesophageal Reflux Disease

Completed NA Last updated 2 January 2020

What this trial tests

NA trial testing PPI in Non-erosive Gatroesophageal Reflux Disease in 62 participants. Completed in 18 October 2019.

Timeline

1 September 2018

Primary endpoint
18 October 2019

18 October 2019

Quick facts

Lead sponsor	Yonsei University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	62
Start date	1 September 2018
Primary completion	18 October 2019
Estimated completion	18 October 2019
Sites	1 location across South Korea

Drugs / interventions tested

PPI — full drug profile →

Conditions studied

Non-erosive Gatroesophageal Reflux Disease — all drugs for Non-erosive Gatroesophageal Reflux Disease →

Sponsor

Yonsei University

Who can join

Adults 19 to 80, any sex, with Non-erosive Gatroesophageal Reflux Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

For ERD(erosive reflux disease), which pathogenesis is mainly the acid reflux mechanism, primary treatment is therefore PPI. However, NERD(non-erosive reflux disease) is much more complex than ERD and there are more factors causing the typical symptoms. As a result, there is no consensus for the treatment of NERD besides using PPI similar to GERD(gastroesophageal reflux diseas). This study intent to evaluate the effect of PPI(Esomezol) on NERD patients and analyze the improvement of symptoms and the factors related to the result.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Treatment of non-erosive reflux disease and dynamics of the esophageal microbiome: a prospective multicenter study.
Park CH, Seo SI, Kim JS, Kang SH, et al · · 2020 · cited 14× · PMID 32938975 · DOI 10.1038/s41598-020-72082-8

Verify or expand the search:

Other trials of PPI

Trials testing the same drug.

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NCT06241833 — Emulation of Randomized Clinical Trial in Cardiovascular Disease · unknown
NCT05815550 — Delirium Related to Proton Pump Inhibitors Use · completed
NCT05020808 — The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise · NA · completed

Other Yonsei University trials

Trials by the same sponsor.

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NCT07507188 — Collaborative Clinical-translational Cohort of Amivantamab Plus Lazertinib and Amivantamab Plus Chemotherapy in Patients · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03436914 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Yonsei University
Last refreshed: 2 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03436914.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing