Last reviewed · How we verify
NCT03431532
Monocyte Subsets Altered by Anesthesia
trial in Regional Anesthesia in 20 participants. Completed in 1 March 2015.
1 January 2015
Quick facts
| Lead sponsor | University Hospital, Saarland |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 1 February 2013 |
| Primary completion | 1 January 2015 |
| Estimated completion | 1 March 2015 |
| Sites | 1 location across Germany |
Conditions studied
- Regional Anesthesia — all drugs for Regional Anesthesia →
- General Anesthesia — all drugs for General Anesthesia →
- Immune Function — all drugs for Immune Function →
Sponsor
University Hospital, Saarland
Who can join
18 and older, male only, with Regional Anesthesia or General Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The impact of different anesthetic techniques on the immune system remains unclear. Aim of this ex vivo / in vitro study was to determine the effects of general and neuraxial anesthesia on monocyte subset alteration and the release of prototypical pro- and anti-inflammatory cytokines. Twenty patients undergoing total knee replacement surgery were randomly assigned to receive either general anesthesia (ITN) or combined spinal/epidural anesthesia (CSE). CD14 and HLA-DR expression patterns on monocytes and intracellular TNF-alpha production were quantified via flow cytometry. TNF-α and IL-10 release were measured via enzyme linked immunosorbent assay (ELISA).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation.
Nieuwenhuijs-Moeke GJ, Bosch DJ, Leuvenink HGD. · · 2021 · cited 12× · PMID 33800423 · DOI 10.3390/ijms22052727
Verify or expand the search:
- PubMed search for NCT03431532
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Hospital, Saarland trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03431532 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Saarland
- Last refreshed: 11 May 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03431532.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing