NCT03422848 (H2O-metabolism) is a NA clinical trial of Water in Glucose, High Blood, sponsored by Region Skane.

Who is sponsoring NCT03422848?

NCT03422848 is sponsored by Region Skane.

What drugs are being tested in NCT03422848?

Interventions in NCT03422848: Water, general life style advice.

What condition does NCT03422848 study?

NCT03422848 studies Glucose, High Blood.

Is NCT03422848 still recruiting?

NCT03422848 is currently completed. Last updated 2 December 2025.

Last reviewed 2025-12-02 · How we verify

NCT03422848: H2O-metabolism

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hydration to Optimize Metabolism

Completed NA Last updated 2 December 2025

What this trial tests

NA trial testing Water in Glucose, High Blood in 797 participants. Completed in 3 November 2025.

Timeline

24 April 2018

Primary endpoint
23 December 2024

3 November 2025

Quick facts

Lead sponsor	Region Skane
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	797
Start date	24 April 2018
Primary completion	23 December 2024
Estimated completion	3 November 2025
Sites	1 location across Sweden

Drugs / interventions tested

Water (WATER) — full drug profile →
general life style advice

Conditions studied

Glucose, High Blood — all drugs for Glucose, High Blood →

Sponsor

Region Skane — full company profile →

Who can join

Adults 20 to 75, any sex, with Glucose, High Blood. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluates hydration (1.5 L of water daily during 1 year) in the lowering of blood glucose concentration in adults with signs of dehydration (elevated levels of the vasopressin marker copeptin and high urine osmolality). Half of participants will in addition to lifestyle advice receive extra water on top of their habitual fluid intake, and the other half (control) will receive only lifestyle advice.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H2O Metabolism Pilot Study.
Enhörning S, Brunkwall L, Tasevska I, Ericson U, et al · · 2019 · cited 46× · PMID 30566641 · DOI 10.1210/jc.2018-02195
Effect of Increased Daily Water Intake and Hydration on Health in Japanese Adults.
Nakamura Y, Watanabe H, Tanaka A, Yasui M, et al · · 2020 · cited 30× · PMID 32340375 · DOI 10.3390/nu12041191
SGLT2 inhibition increases serum copeptin in young adults with type 1 diabetes.
Lytvyn Y, Bjornstad P, Katz A, Singh SK, et al · · 2020 · cited 19× · PMID 31816431 · DOI 10.1016/j.diabet.2019.11.006
Investigation of possible underlying mechanisms behind water-induced glucose reduction in adults with high copeptin.
Enhörning S, Vanhaecke T, Dolci A, Perrier ET, et al · · 2021 · cited 8× · PMID 34966186 · DOI 10.1038/s41598-021-04224-5
Short-term association between outdoor temperature and the hydration-marker copeptin: a pooled analysis in five cohorts.
Timpka S, Melander O, Engström G, Elmståhl S, et al · · 2023 · cited 2× · PMID 37556945 · DOI 10.1016/j.ebiom.2023.104750
The Impact of Hydration on Metabolic Outcomes: From Arginine-Vasopressin Signaling to Clinical Implications.
Koceva A, Janež A, Jensterle M. · · 2025 · cited 1× · PMID 40428796 · DOI 10.3390/medicina61050838
Response to Letter to the Editor: "Water Supplementation Reduces Copeptin and Plasma Glucose in Adults with High Copeptin: The H2O Metabolism Pilot Study".
Enhörning S, Melander O. · · 2020 · PMID 31665344 · DOI 10.1210/clinem/dgz085

Verify or expand the search:

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Trials testing the same drug.

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Other Region Skane trials

Trials by the same sponsor.

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NCT07494669 — Proteomics and Physiological Parameters Predicting Complications After Colorectal Cancer Surgery · not yet recruiting
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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03422848 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Region Skane
Last refreshed: 2 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03422848.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing