NCT03418662 is a NA clinical trial of EndoRings device in Colorectal Adenoma, sponsored by Indiana University.

Who is sponsoring NCT03418662?

NCT03418662 is sponsored by Indiana University.

What drugs are being tested in NCT03418662?

Interventions in NCT03418662: EndoRings device.

What condition does NCT03418662 study?

NCT03418662 studies Colorectal Adenoma, Colorectal Polyp, Colon Cancer.

Is NCT03418662 still recruiting?

NCT03418662 is currently completed. Last updated 20 September 2019.

Are results published for NCT03418662?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2019-09-20 · How we verify

NCT03418662

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

EndoRings Colonoscopy vs Standard Colonoscopy

Completed NA Results posted Last updated 20 September 2019

What this trial tests

NA trial testing EndoRings device in Colorectal Adenoma in 592 participants. Completed in 13 September 2018.

Timeline

19 January 2018

Primary endpoint
13 September 2018

13 September 2018

Quick facts

Lead sponsor	Indiana University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	screening
Enrollment	592
Start date	19 January 2018
Primary completion	13 September 2018
Estimated completion	13 September 2018
Sites	1 location across United States

Drugs / interventions tested

EndoRings device

Conditions studied

Colorectal Adenoma — all drugs for Colorectal Adenoma →
Colorectal Polyp — all drugs for Colorectal Polyp →
Colon Cancer — all drugs for Colon Cancer →

Sponsor

Indiana University

Who can join

Eligibility, any sex, with Colorectal Adenoma or Colorectal Polyp. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Adenoma Detection Rates Primary · During colonoscopy procedure

Number of participants with at least one adenoma detected, during Standard Colonoscopy compared with colonoscopy with EndoRings.

Group	Value	95% CI
EndoRings Colonoscopy	143
Control Arm (Standard Colonoscopy)	124

Number of Adenomas Per Colonoscopy Primary · During colonoscopy procedure

Comparison of the number of adenomas detected per colonoscopy between standard colonoscopy and EndoRings colonoscopy.

Group	Value	95% CI
EndoRings Colonoscopy	1.46	± 2.69
Control Arm (Standard Colonoscopy)	1.06	± 1.83

Polyp Detection Rate Secondary · During colonoscopy procedure

Number of subjects with at least one polyp detected with Standard Colonoscopy compared to colonoscopy with EndoRings.

Group	Value	95% CI
EndoRings Colonoscopy	199
Control Arm (Standard Colonoscopy)	188

Number of Detections Per Colonoscopy Secondary · During colonoscopy procedure

Comparison of the number of polyps detected per colonoscopy between EndoRings colonoscopy and Standard colonoscopy.

Group	Value	95% CI
EndoRings Colonoscopy	2.29	± 3.09
Control Arm (Standard Colonoscopy)	1.82	± 2.19

Total Number of Detections Secondary · During colonoscopy procedure

Comparison of the total number of polyps detected and the total number of adenomas detected between EndoRings colonoscopy and Standard colonoscopy.

Polyps

Group	Value	95% CI
EndoRings Colonoscopy	415
Control Arm (Standard Colonoscopy)	295

Adenomas

Group	Value	95% CI
EndoRings Colonoscopy	650
Control Arm (Standard Colonoscopy)	506

Cecal Intubation Rate Secondary · During colonoscopy procedure

Comparison of cecal intubation rate (the number of procedures where the colonoscope was able to be inserted all the way to the cecum) between standard colonoscopy and EndoRings colonoscopy.

Group	Value	95% CI
EndoRings Colonoscopy	281
Control Arm (Standard Colonoscopy)	277

Time Comparison for Each Method Secondary · During colonoscopy procedure

Comparison of the time required to reach the cecum, withdrawal time, and total procedure time. Insertion time: time required to reach the cecum Withdrawal time: time calculated from when withdrawing is started in the cecum till the colonoscope is removed. This includes time spent washing, inspecting the colon and removing polyps. Total procedure time: This is the sum of insertion and withdrawal times along with any time spent washing or removing polyps while in the cecum (before starting withdrawal).

Insertion Time

Group	Value	95% CI
EndoRings Colonoscopy	6.3	± 4.4
Control Arm (Standard Colonoscopy)	5.5	± 3.4

Total Withdrawal Time

Group	Value	95% CI
EndoRings Colonoscopy	11.8	± 6.1
Control Arm (Standard Colonoscopy)	12.8	± 5.9

Total Procedure Time

Group	Value	95% CI
EndoRings Colonoscopy	19.4	± 8.2
Control Arm (Standard Colonoscopy)	19.5	± 7.9

Patient Comfort Score Secondary · After colonoscopy was completed while patient was in recovery area of endoscopy unit

Comparison of patient comfort between Standard colonoscopy and EndoRings colonoscopy on a scale of 0 to 10 with 0 being no pain (best outcome) and 10 being worst imaginable pain (worst outcome).

Group	Value	95% CI
EndoRings Colonoscopy	0.47	± 1.1
Control Arm (Standard Colonoscopy)	0.36	± 0.9

Problems Encountered With Equipment Secondary · During colonoscopy procedure

Occurrences of slippage of EndoRings or of device being removed on insertion.

Procedures with slippage of device

Group	Value	95% CI
EndoRings Colonoscopy	17

Procedures where device was removed

Group	Value	95% CI
EndoRings Colonoscopy	25

Sponsor's own description

The study aims to compare the results between a standard colonoscopy to a colonoscopy with an attachment on the distal end of the colonoscope.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Impact of a ring-fitted cap on insertion time and adenoma detection: a randomized controlled trial.
Rex DK, Kessler WR, Sagi SV, Rogers NA, et al · · 2020 · cited 14× · PMID 31299257 · DOI 10.1016/j.gie.2019.06.042

Verify or expand the search:

Other recruiting trials for Colorectal Adenoma

Currently open trials in the same condition.

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Other Indiana University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03418662 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Indiana University
Last refreshed: 20 September 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03418662.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing