Last reviewed · How we verify
NCT03417271
Short Pulse Width DBS in Parkinson's Disease
Phase 2 trial testing Deep brain stimulation in Parkinson's Disease in 16 participants. Completed in 24 October 2018.
24 October 2018
Quick facts
| Lead sponsor | University College, London |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 16 |
| Start date | 2 May 2018 |
| Primary completion | 24 October 2018 |
| Estimated completion | 24 October 2018 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Deep brain stimulation
Conditions studied
- Parkinson's Disease — all drugs for Parkinson's Disease →
Sponsor
University College, London
Who can join
Eligibility, any sex, with Parkinson's Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this investigation is to explore the effect of reducing conventional pulse width of stimulation on known adverse effects of Subthalamic nucleus Deep Brain Stimulation (STN DBS) treatment such as; slurring of speech, gait impairment, and unsteadiness. This investigation is designed such that each of 16 patients (who have all had chronically implanted DBS systems), will be assessed using conventional (DBS-60µs) and short (DBS-30µs) pulse width DBS, in a randomised order.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Clinical trials for cognition in Parkinson's disease: Where are we and how can we do better?
Bayram E, Batzu L, Tilley B, Gandhi R, et al · · 2023 · cited 13× · PMID 37031010 · DOI 10.1016/j.parkreldis.2023.105385
Verify or expand the search:
- PubMed search for NCT03417271
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Deep brain stimulation
Trials testing the same drug.
- NCT07458217 — Combined CM and STN Stimulation for Motor Epilepsy · NA · not yet recruiting
- NCT05897775 — Coordinated Reset Deep Brain Stimulation for Essential Tremor · Phase 1 · recruiting
- NCT05437393 — Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot · NA · completed
- NCT04650932 — Dual Frequency Stimulation in Parkinson's Disease · NA · recruiting
- NCT05397340 — Asymmetric Targeted DBS for PD With PIGD · NA · unknown
Other recruiting trials for Parkinson's Disease
Currently open trials in the same condition.
- NCT07371338 — Phase 1 Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of IPS101A in Parkinson's Disease Patients · Phase 1 · recruiting
- NCT07330258 — A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite · recruiting
- NCT07384429 — Effects of Lemborexant on Motor-sleep Comorbidity in Parkinson's Disease · Phase 4 · recruiting
- NCT07384442 — Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's · NA · recruiting
- NCT06562569 — Non-invasive VNS for PD Gait · NA · recruiting
Other University College, London trials
Trials by the same sponsor.
- NCT07386652 — Intensive Comprehensive Aphasia Programme for People With Post-Stroke Aphasia · NA · not yet recruiting
- NCT06924086 — The Children's Adaptive Deep Brain Stimulation for Epilepsy Trial · NA · recruiting
- NCT07386678 — Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment · not yet recruiting
- NCT07414940 — ACTinium in Castrate-RESistant Prostate Cancer After LUTEtium · Phase 1, PHASE2 · not yet recruiting
- NCT07214454 — TCDS for the Treatment of Chronic Migraine · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03417271 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University College, London
- Last refreshed: 17 April 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03417271.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing