NCT03391908 (MultiPlaque) is a clinical trial of cardiac imaging tests in Coronary Stenosis, sponsored by Cardio Med Medical Center.

Who is sponsoring NCT03391908?

NCT03391908 is sponsored by Cardio Med Medical Center.

What drugs are being tested in NCT03391908?

Interventions in NCT03391908: cardiac imaging tests.

What condition does NCT03391908 study?

NCT03391908 studies Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atheromatous Plaques, Atherosclerosis, Unstable Angina, Non-ST Elevation Myocardial Infarction.

Is NCT03391908 still recruiting?

NCT03391908 is currently completed. Last updated 2 August 2022.

Last reviewed 2022-08-02 · How we verify

NCT03391908: MultiPlaque

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Multiomics and Imaging-based Assessment of Vulnerable Coronary Plaques in Acute Coronary Syndromes

Completed Last updated 2 August 2022

What this trial tests

trial testing cardiac imaging tests in Coronary Stenosis in 100 participants. Completed in 31 January 2021.

Timeline

1 April 2018

Primary endpoint
30 September 2020

31 January 2021

Quick facts

Lead sponsor	Cardio Med Medical Center
Status	Completed
Study type	OBSERVATIONAL
Enrollment	100
Start date	1 April 2018
Primary completion	30 September 2020
Estimated completion	31 January 2021
Sites	1 location across Romania

Drugs / interventions tested

cardiac imaging tests

Conditions studied

Coronary Stenosis — all drugs for Coronary Stenosis →
Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
Acute Myocardial Infarction — all drugs for Acute Myocardial Infarction →
Atheromatous Plaques — all drugs for Atheromatous Plaques →

Sponsor

Cardio Med Medical Center

Who can join

18 and older, any sex, with Coronary Stenosis or Acute Coronary Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of Multiplaque clinical study is to assess the vulnerability degree of the atheromatous plaques, before and after a myocardial infarction (MI), based on multiomics analysis, associated with invasive and non-invasive data. In this study, a multi-parametric model for risk prediction will be developed, for evaluation of the risk that is associated with the vulnerable coronary plaques in patients that have suffered an acute coronary syndrome. In the study, evaluation of the imaging characteristics of these coronary plaques will be performed with the use of CT, OCT, IVUS and invasive angiography. We will study the correlation between plaque evolution and (1) the degree of vulnerability at baseline, (2) multiomics profile of the patients and (3) clinical evolution during follow-up. Also, new techniques for evaluation of the functional significance of coronary stenoses will be studied and validated, such as calculation of the fractional flow reserve or determination of shear stress in areas that are localized within the near vicinity of the vulnerable coronary plaques.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Network Medicine: A Clinical Approach for Precision Medicine and Personalized Therapy in Coronary Heart Disease.
Infante T, Del Viscovo L, De Rimini ML, Padula S, et al · · 2020 · cited 30× · PMID 31723086 · DOI 10.5551/jat.52407

Verify or expand the search:

Other trials of cardiac imaging tests

Trials testing the same drug.

NCT03395041 — Periodontal Disease, Inflammation and Acute Coronary Syndromes · completed

Other recruiting trials for Coronary Stenosis

Currently open trials in the same condition.

NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
NCT06542393 — PBM as Strategy to CABG Anemic Patients Bypass Graft (CABG) · Phase 2 · recruiting
NCT05709652 — Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup · NA · recruiting
NCT06376630 — Study of Microvascular Dysfunction, CFR and Cardioprotective Effect of Early Administration of Esmolol in MI · NA · recruiting
NCT04014140 — iFR Guided Coronary Artery Bypass Grafting Surgery · recruiting

Other Cardio Med Medical Center trials

Trials by the same sponsor.

NCT04680689 — Assessment of Lesion-Associated Myocardial Ischemia Based on Fusion Coronary CT Imaging · completed
NCT04397198 — The Assessment Of Myocardial Viability Based On CTA/MRI Hybrid Models · completed
NCT04161378 — Impact of Cardiac Rehabilitation Programs on Left Ventricular Remodeling After Acute Myocardial Infarction - the REHAB T · completed
NCT03830944 — Inflammation-mediated Coronary Plaque Vulnerability, Myocardial Viability and Ventricular Remodeling · completed
NCT03757741 — Inflammation, Fibrosis and Risk of Recurrence After Atrial Fibrillation Ablation · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03391908 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Cardio Med Medical Center
Last refreshed: 2 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03391908.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing