NCT03391427 is a NA clinical trial of Lidocaine in Hepatectomy, sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's.

What drugs are being tested in NCT03391427?

Interventions in NCT03391427: Lidocaine, Ketamine, Lidocaine+ketamine, Saline.

What condition does NCT03391427 study?

NCT03391427 studies Hepatectomy.

Is NCT03391427 still recruiting?

NCT03391427 is currently completed. Last updated 6 July 2023.

Last reviewed 2023-07-06 · How we verify

NCT03391427

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection

Completed NA Last updated 6 July 2023

What this trial tests

NA trial testing Lidocaine in Hepatectomy in 124 participants. Completed in 30 December 2017.

Timeline

1 March 2011

Primary endpoint
4 November 2015

30 December 2017

Quick facts

Lead sponsor	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	124
Start date	1 March 2011
Primary completion	4 November 2015
Estimated completion	30 December 2017
Sites	1 location across Canada

Drugs / interventions tested

Lidocaine — full drug profile →
Ketamine (ketamine) — full drug profile →
Lidocaine+ketamine
Saline

Conditions studied

Hepatectomy — all drugs for Hepatectomy →

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Who can join

Adults 18 to 80, any sex, with Hepatectomy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Lidocaine and ketamine both are being used for perioperative analgesia. Perioperative lidocaine infusion has been shown to reduce postoperative pain and opioid consumption. Perioperative low dose Ketamine has shown improved postoperative pain and reduced opioid usage. We therefore tested the hypothesis that the combination would provide better analgesia in the milieu of intrathecal morphine.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Lidocaine

Trials testing the same drug.

NCT07488832 — Intravenous Lidocaine Infusion in Lumbar Fusion Surgery · NA · recruiting
NCT07445191 — Efficacy of Triamcinolone-Lidocaine Mix in Trigger Points Injection of Masseter Muscle: Double-blinded, Randomized Contr · Phase 2, PHASE3 · not yet recruiting
NCT07422558 — Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain · NA · not yet recruiting
NCT06923787 — Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patient · Phase 2 · recruiting
NCT07355049 — The Effect of Dexmedetomidine Versus Lidocaine on Emergence Agitation. · NA · not yet recruiting

Other recruiting trials for Hepatectomy

Currently open trials in the same condition.

NCT07507643 — A Study of Methylprednisolone in People Having Liver Surgery · Phase 3 · recruiting
NCT07062380 — AI-Based Prediction of HCC Recurrence Patterns After Resection (APAR) · recruiting
NCT06950827 — Textbook Outcomes of Right Hemihepatectomy in Patients With Hepatocellular Carcinoma · recruiting
NCT07385521 — The Use of Artificial Intelligence for the Prediction of Recurrence After Resection of Colorectal Liver Metastases · recruiting
NCT06237751 — Preoperative Sildenafil Administration for Hepatectomy · NA · recruiting

Other London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials

Trials by the same sponsor.

NCT07588711 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury · NA · not yet recruiting
NCT07585292 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy · NA · not yet recruiting
NCT07510906 — Evaluation of a Prostate-Targeted PET Imaging System (P-PET) for Detecting Prostate Cancer · NA · not yet recruiting
NCT03166072 — Health Education vs Meditation in Irreversible Age-Related Vision Loss Patients and Their Caregivers · NA · not yet recruiting
NCT06035809 — Sensory Motor Arousal Regulation Treatment (SMART) Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03391427 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Last refreshed: 6 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03391427.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing