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NCT03388242

Protein and microRNA Markers for Early Detection of Alzheimer's Disease

Withdrawn Last updated 23 June 2023
What this trial tests

trial testing No intervention in Mild Cognitive Impairment. Withdrawn.

Timeline
7 December 2017
Primary endpoint
30 March 2020
30 March 2020

Quick facts

Lead sponsorSun Yat-sen University
StatusWithdrawn
Study typeOBSERVATIONAL
Start date7 December 2017
Primary completion30 March 2020
Estimated completion30 March 2020
Sites2 locations across China

Drugs / interventions tested

Conditions studied

Sponsor

Sun Yat-sen University

Who can join

Adults 30 to 80, any sex, with Mild Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Blood will be harvested from three groups of people, normal control, patients with mild cognitive impairment (MCI) and patients with Alzheimer's disease (AD), 20 people per group. The blood samples will be used to determine the difference in the expression of microRNAs and proteins. Blood samples will be harvested again at 6-month interval from patients. The combination of the microRNAs and proteins that have different expression patterns between normal control and patients with MCI will be constructed in a kit to detect the difference. This kit will be used in another set of the three groups of people to determine its sensitivity and specificity in detecting patients with MCI.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

  1. MicroRNAs as Potential Orchestrators of Alzheimer's Disease-Related Pathologies: Insights on Current Status and Future Possibilities.
    Abuelezz NZ, Nasr FE, AbdulKader MA, Bassiouny AR, et al · · 2021 · cited 45× · PMID 34712129 · DOI 10.3389/fnagi.2021.743573
  2. MicroRNA Networks in Cognition and Dementia.
    Blount GS, Coursey L, Kocerha J. · · 2022 · cited 22× · PMID 35741010 · DOI 10.3390/cells11121882
  3. Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases.
    Ma YM, Zhao L. · · 2023 · cited 14× · PMID 38058356 · DOI 10.1155/2023/8537296

Verify or expand the search:

Other trials of No intervention

Trials testing the same drug.

Other recruiting trials for Mild Cognitive Impairment

Currently open trials in the same condition.

Other Sun Yat-sen University trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

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