NCT03375684

Effects of Inspiratory Muscle Training on Postural Stability, Balance, Pulmonary Function and Functional Capacity in Children With Cystic Fibrosis

Completed NA Last updated 23 May 2018

What this trial tests

NA trial testing Conventional chest physiotherapy in Cystic Fibrosis in 32 participants. Completed in 21 May 2018.

Timeline

2 January 2018

Primary endpoint
2 May 2018

21 May 2018

Quick facts

Lead sponsor	Bezmialem Vakif University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	32
Start date	2 January 2018
Primary completion	2 May 2018
Estimated completion	21 May 2018
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Conventional chest physiotherapy
• Inspiratory muscle training

Conditions studied

• Cystic Fibrosis — all drugs for Cystic Fibrosis →

Sponsor

Bezmialem Vakif University

Who can join

Adults 8 to 18, any sex, with Cystic Fibrosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

It is extensively reported in the literature that patients with chronic obstructive lung disease may have impairments in balance and postural control which further increase the disease burden. Mechanisms related to these impairments include, but are not limited to increased work of breathing, diaphragm weakness, peripheral muscle weakness and systemic inflammation. Since the similar symptoms are reported for the children with cystic fibrosis, it is hypothesized that balance and postural control may also be compromised in these patients. Inspiratory muscle training (IMT) is shown to improve diaphragm strength and pulmonary function. Considering the relation between diaphragm which is one of the core muscles, and balance, IMT may also have an impact on postural control and balance alongside the standard clinical parameters such as respiratory muscle strength, pulmonary function and functional capacity in these patients. Thus, the aim of this study was to investigate the effects of inspiratory muscle training and conventional chest physiotherapy on postural stability, balance, pulmonary function and functional capacity in children with cystic fibrosis.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effects of inspiratory muscle training on postural stability, pulmonary function and functional capacity in children with cystic fibrosis: A randomised controlled trial.
   Zeren M, Cakir E, Gurses HN. · · 2019 · cited 25× · PMID 30827470 · DOI 10.1016/j.rmed.2019.01.013
2. The effect of respiratory muscle training on children and adolescents with cystic fibrosis: a systematic review and meta-analysis.
   Cai W, Li M, Xu Y, Li M, et al · · 2024 · cited 5× · PMID 38622583 · DOI 10.1186/s12887-024-04726-x