NCT03371888 (PRP/TMD) is a Phase 2, PHASE3 clinical trial of Platelet-Rich Plasma intramuscular injections in PRP, sponsored by Medical University of Silesia.

Who is sponsoring NCT03371888?

NCT03371888 is sponsored by Medical University of Silesia.

What drugs are being tested in NCT03371888?

Interventions in NCT03371888: Platelet-Rich Plasma intramuscular injections, Placebo Comparator: 0,9% NaCl intramuscular injections.

What condition does NCT03371888 study?

NCT03371888 studies PRP, Temporomandibular Disorder, Myalgia, Bruxism.

Is NCT03371888 still recruiting?

NCT03371888 is currently completed. Last updated 4 January 2019.

Last reviewed 2019-01-04 · How we verify

NCT03371888: PRP/TMD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Platelet-Rich Plasma in the Therapy of Temporomandibular Disorders

Completed Phase 2, PHASE3 Last updated 4 January 2019

What this trial tests

Phase 2, PHASE3 trial testing Platelet-Rich Plasma intramuscular injections in PRP in 58 participants. Completed in 1 January 2019.

Timeline

7 December 2017

Primary endpoint
15 December 2018

1 January 2019

Quick facts

Lead sponsor	Medical University of Silesia
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	58
Start date	7 December 2017
Primary completion	15 December 2018
Estimated completion	1 January 2019
Sites	1 location across Poland

Drugs / interventions tested

Platelet-Rich Plasma intramuscular injections — full drug profile →
Placebo Comparator: 0,9% NaCl intramuscular injections — full drug profile →

Conditions studied

PRP — all drugs for PRP →
Temporomandibular Disorder — all drugs for Temporomandibular Disorder →
Myalgia — all drugs for Myalgia →
Bruxism — all drugs for Bruxism →

Sponsor

Medical University of Silesia

Who can join

Adults 23 to 42, any sex, with PRP or Temporomandibular Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Platelet-Rich Plasma intramuscular injections into the masseter and temporalis muscle were performed to reduce painful temporomandibular disorder symptoms,such as myalgia, myofascial pain and myofascial pain with referrals. Patients(n=120) were randomly divided into two groups: experimental(n=60) and control group(n=60). In controls injections with 0,9% NaCl were performed. Pain intensity was measured with NPRS (numeriic pain rating scale, 0= no pain, 11= the worst pain that one can imagine) before(0 day), during(10 day) and after(20 day) the therapy with PRP injections.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Platelet-Rich Plasma Intramuscular Injections - Antinociceptive Therapy in Myofascial Pain Within Masseter Muscles in Temporomandibular Disorders Patients: A Pilot Study.
Nitecka-Buchta A, Walczynska-Dragon K, Kempa WM, Baron S. · · 2019 · cited 21× · PMID 30941095 · DOI 10.3389/fneur.2019.00250
Evolution and mechanistic insights of platelet-derived products in temporomandibular joint regeneration.
Lin C, Jin Y, Li D, Yang Q, et al · · 2026 · PMID 41646866 · DOI 10.3389/fcell.2026.1776592

Verify or expand the search:

Other recruiting trials for PRP

Currently open trials in the same condition.

NCT07470359 — Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and With · Phase 2 · recruiting
NCT06472323 — The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for the Trigeminal Neuralgia · recruiting
NCT06028009 — PRP Injections for Genitourinary Syndrome of Menopause · NA · active not recruiting
NCT05412381 — PRP in ACLR to Prevent PTOA · Phase 3 · recruiting
NCT05279560 — Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation · NA · active not recruiting

Other Medical University of Silesia trials

Trials by the same sponsor.

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NCT07137299 — POPQ Associated With Total Laparoscopic Hysterectomy · not yet recruiting
NCT06970041 — To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated · NA · not yet recruiting
NCT07120529 — Minimally Invasive Surgery Versus Open Radical Hysterectomy in Presumably Early Stage Cervical Cancer: a Retrospective M · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03371888 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Silesia
Last refreshed: 4 January 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03371888.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing