NCT03349905 (DEFETOSE) is a NA clinical trial of fresh transfer in Infertility, Female, sponsored by Assistance Publique - Hôpitaux de Paris.

Who is sponsoring NCT03349905?

NCT03349905 is sponsored by Assistance Publique - Hôpitaux de Paris.

What drugs are being tested in NCT03349905?

Interventions in NCT03349905: fresh transfer, Deferred-frozen embryo transfer.

What condition does NCT03349905 study?

NCT03349905 studies Infertility, Female.

Is NCT03349905 still recruiting?

NCT03349905 is currently completed. Last updated 31 March 2026.

Last reviewed 2026-03-31 · How we verify

NCT03349905: DEFETOSE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Deferred Versus Fresh Embryo Transfers

Completed NA Last updated 31 March 2026

What this trial tests

NA trial testing fresh transfer in Infertility, Female in 237 participants. Completed in 31 March 2022.

Timeline

24 September 2018

Primary endpoint
19 January 2022

31 March 2022

Quick facts

Lead sponsor	Assistance Publique - Hôpitaux de Paris
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	237
Start date	24 September 2018
Primary completion	19 January 2022
Estimated completion	31 March 2022
Sites	1 location across France

Drugs / interventions tested

fresh transfer
Deferred-frozen embryo transfer

Conditions studied

Infertility, Female — all drugs for Infertility, Female →

Sponsor

Assistance Publique - Hôpitaux de Paris — full company profile →

Who can join

Adults 18 to 40, female only, with Infertility, Female. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Controlled ovarian stimulation (COS) enhances the efficacy of ART (Assisted reproductive technology) by permitting multiple-oocyte yields, but also alters endometrial receptivity (ER) by an advancement of endometrial development which contributes to diminished pregnancy chances. Previous reports suggest that pregnancy rates are increased following deferred frozen embryo transfers. In addition as compared to fresh embryo transfers, frozen embryo transfers seem to be associated with less affected perinatal outcomes, in particular lower risk of preterm birth, small for gestational age and caesarean section. Unfortunately, most of the current evidence is based only on preliminary reports, needing further scientific evidence. Thus, whether differing embryo transfers could restore optimal ER leading to higher live birth rate (LBR) and better obstetrical outcomes as compared to fresh embryo transfers, is actually still under investigation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Fresh versus frozen embryo transfers in assisted reproduction.
Zaat T, Zagers M, Mol F, Goddijn M, et al · · 2021 · cited 119× · PMID 33539543 · DOI 10.1002/14651858.cd011184.pub3

Verify or expand the search:

Other recruiting trials for Infertility, Female

Currently open trials in the same condition.

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NCT07175571 — SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques · NA · recruiting
NCT06193135 — Usefulness of Corifollitropin α as Alternative to Conventional Daily rFSH Protocols in Oocyte Donors Undergoing Pituitar · NA · recruiting

Other Assistance Publique - Hôpitaux de Paris trials

Trials by the same sponsor.

NCT07443436 — Immunomodulatory Treatment of Interstitial Lung Disease Associated With Surfactant Related Gene Variants · Phase 2 · not yet recruiting
NCT07499492 — Red Blood Cell Transfusion to Optimize Extubation · NA · not yet recruiting
NCT07379918 — Real-life Evaluation of Endopredict® in Early HR+/HER2- Breast Cancer · recruiting
NCT07473869 — Smartphone Application for Automated Measurement of Capillary Refill Time (CRT) · not yet recruiting
NCT07505394 — Efficacy of a Prediction Model-based Algorithm to PREVENT Drug-induced Impulse Control Disorders in Parkinson's Disease · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03349905 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Assistance Publique - Hôpitaux de Paris
Last refreshed: 31 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03349905.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing