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NCT03339635
Short-term Testosterone Replacement in Testicular Cancer Survivors
Phase 2 trial testing Androgel (Testosterone gel) in Testicular Cancer in 32 participants. Completed in 26 June 2024.
26 June 2024
Quick facts
| Lead sponsor | University Medical Center Groningen |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 32 |
| Start date | 21 December 2018 |
| Primary completion | 26 June 2024 |
| Estimated completion | 26 June 2024 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Androgel (Testosterone gel) — full drug profile →
- Placebo gel
Conditions studied
- Testicular Cancer — all drugs for Testicular Cancer →
Sponsor
University Medical Center Groningen
Who can join
Adults 18 to 55, male only, with Testicular Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To assess the effects of testosterone replacement therapy on fat mass and other components of the metabolic syndrome. A randomized double-blind placebo controlled intervention study, followed by an open-label treatment phase. Results of this pilot study will be used to design a multicenter randomized controlled study in a large group of TC survivors
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Vascular aging in long-term survivors of testicular cancer more than 20 years after treatment with cisplatin-based chemotherapy.
Stelwagen J, Lubberts S, Steggink LC, Steursma G, et al · · 2020 · cited 21× · PMID 32921790 · DOI 10.1038/s41416-020-01049-3 -
Adverse Health Outcomes in Relationship to Hypogonadism After Chemotherapy: A Multicenter Study of Testicular Cancer Survivors.
Abu Zaid M, Dinh PC, Monahan PO, Fung C, et al · · 2019 · cited 19× · PMID 31085753 · DOI 10.6004/jnccn.2018.7109 -
Cognitive Impairment in Long-Term Survivors of Testicular Cancer More Than 20 Years after Treatment.
Stelwagen J, Meuleman AT, Lubberts S, Steursma G, et al · · 2021 · cited 8× · PMID 34830829 · DOI 10.3390/cancers13225675
Verify or expand the search:
- PubMed search for NCT03339635
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Testicular Cancer
Currently open trials in the same condition.
- NCT07498959 — Primary RPLND Versus Systemic Chemotherapy in Good-prognosis Metastatic Testicular Cancer · NA · recruiting
- NCT07124000 — DESTINY-PANTUMOUR04 · recruiting
- NCT07106827 — A Study of GV20-0251 in Advanced or Refractory Solid Tumors · Phase 1 · recruiting
- NCT07228637 — Pursuing Exploration Into the Supportive Care Needs and Intervention Preferences of Survivors of Testicular Cancer · NA · active not recruiting
- NCT06932458 — A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retr · Phase 2 · recruiting
Other University Medical Center Groningen trials
Trials by the same sponsor.
- NCT06647602 — Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy · not yet recruiting
- NCT06809946 — Feasibility of Fluorescence Imaging With Bevacizumab-800CW During Bronchoscopy · Phase 2 · not yet recruiting
- NCT07527390 — CANagliflozin In DIALysis Patients · Phase 4 · not yet recruiting
- NCT07439237 — Implant-supported Maxillary Overdentures; a 15-years Evaluation · not yet recruiting
- NCT07275437 — Effectiveness and Safety of Uptitration of Guideline Directed MEdical Therapy in Heart Failure With Reduced Ejection Fra · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03339635 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Medical Center Groningen
- Last refreshed: 30 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03339635.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing