NCT03335124 is a Phase 4 clinical trial of Vitamin C in Sepsis, sponsored by University Medical Centre Ljubljana.

Who is sponsoring NCT03335124?

NCT03335124 is sponsored by University Medical Centre Ljubljana.

What drugs are being tested in NCT03335124?

Interventions in NCT03335124: Vitamin C, Hydrocortisone, Thiamine, 0.9% Sodium Chloride Injection.

What condition does NCT03335124 study?

NCT03335124 studies Sepsis, Septic Shock, Critical Illness, Fluid Overload.

Is NCT03335124 still recruiting?

NCT03335124 is currently terminated. Last updated 19 February 2019.

Last reviewed 2019-02-19 · How we verify

NCT03335124

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock

Terminated Phase 4 Last updated 19 February 2019

What this trial tests

Phase 4 trial testing Vitamin C in Sepsis in 5 participants. Terminated before completion.

Timeline

26 September 2017

Primary endpoint
1 December 2018

1 December 2018

Quick facts

Lead sponsor	University Medical Centre Ljubljana
Phase	Phase 4
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	5
Start date	26 September 2017
Primary completion	1 December 2018
Estimated completion	1 December 2018
Sites	1 location across Slovenia

Drugs / interventions tested

Vitamin C — full drug profile →
Hydrocortisone (hydrocortisone) — full drug profile →
Thiamine (THIAMINE) — full drug profile →
0.9% Sodium Chloride Injection

Conditions studied

Sepsis — all drugs for Sepsis →
Septic Shock — all drugs for Septic Shock →
Critical Illness — all drugs for Critical Illness →
Fluid Overload — all drugs for Fluid Overload →

Sponsor

University Medical Centre Ljubljana

Who can join

18 and older, any sex, with Sepsis or Septic Shock. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The global burden of sepsis is substantial with an estimated 15 to 19 million cases per year; the vast majority of these cases occur in low income countries. New therapeutic approaches to sepsis are desperately required; considering the global burden of sepsis these interventions should be effective, cheap, safe and readily available. The aim is to study the synergistic effect of vitamin C, hydrocortisone and thiamine on survival in patients with severe sepsis and septic shock.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation.
Moskowitz A, Andersen LW, Huang DT, Berg KM, et al · · 2018 · cited 91× · PMID 30373647 · DOI 10.1186/s13054-018-2217-4
Corticosteroids for treating sepsis in children and adults.
Annane D, Bellissant E, Bollaert PE, Briegel J, et al · · 2019 · cited 76× · PMID 31808551 · DOI 10.1002/14651858.cd002243.pub4
The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.
Hager DN, Hooper MH, Bernard GR, Busse LW, et al · · 2019 · cited 47× · PMID 30953543 · DOI 10.1186/s13063-019-3254-2
Doctor-your septic patients have scurvy!
Marik PE, Hooper MH. · · 2018 · cited 26× · PMID 29378661 · DOI 10.1186/s13054-018-1950-z
Steroids for sepsis: yes, no or maybe.
Marik PE. · · 2018 · cited 12× · PMID 29849191 · DOI 10.21037/jtd.2018.04.35
Corticosteroids for treating sepsis in children and adults.
Annane D, Briegel J, Granton D, Bellissant E, et al · · 2025 · cited 7× · PMID 40470636 · DOI 10.1002/14651858.cd002243.pub5

Verify or expand the search:

Other trials of Vitamin C

Trials testing the same drug.

NCT07476443 — Renoprotective Role of Vitamin C and Coenzyme Q10 in Nephrotoxicity · Phase 2, PHASE3 · not yet recruiting
NCT07414693 — Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia · Phase 4 · recruiting
NCT06971315 — Impact of Vitamin C on Pain Detection and Tolerance Threshold · NA · completed
NCT06794255 — Exploratory Study on the Role of Vitamin C in Promoting Health in Middle-Aged and Elderly Adults · NA · recruiting
NCT07341308 — Does Vitamin C Increase the Body Heat Generated By The Nervous System? · NA · recruiting

Other recruiting trials for Sepsis

Currently open trials in the same condition.

NCT07507877 — Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness · recruiting
NCT07154615 — Assessing Immune Dysfunction in Sepsis · recruiting
NCT07419802 — OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study · recruiting
NCT07351344 — African Survey on Sepsis Knowledge (ASK) · recruiting
NCT07448805 — Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit · NA · recruiting

Other University Medical Centre Ljubljana trials

Trials by the same sponsor.

NCT07466472 — Image-Guided Central Catheter Insertion With Concurrent Assessment of Vascular Wall Integrity · not yet recruiting
NCT07446244 — Catheter Ablation of Advanced Forms of Atrial Fibrillation · NA · enrolling by invitation
NCT07109076 — Effect of Immediate Skin-to-Skin Contact on Neonatal Heart Rate Variability After Cesarean Secton · NA · recruiting
NCT07354880 — Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease · Phase 4 · not yet recruiting
NCT07496736 — Post-exposure Influenza Prophylaxis in a Hospital Setting · Phase 3 · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03335124 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Medical Centre Ljubljana
Last refreshed: 19 February 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03335124.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing