NCT03330210 (LAA-PrintRegis) is a clinical trial of 3D printing in Atrial Fibrillation, sponsored by University Hospital, Montpellier.

Who is sponsoring NCT03330210?

NCT03330210 is sponsored by University Hospital, Montpellier.

What drugs are being tested in NCT03330210?

Interventions in NCT03330210: 3D printing.

What condition does NCT03330210 study?

NCT03330210 studies Atrial Fibrillation.

Is NCT03330210 still recruiting?

NCT03330210 is currently completed. Last updated 10 March 2020.

Last reviewed 2020-03-10 · How we verify

NCT03330210: LAA-PrintRegis

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Left Atrial Appendage Occlusion Guided by 3D Printing

Completed Last updated 10 March 2020

What this trial tests

trial testing 3D printing in Atrial Fibrillation in 400 participants. Completed in 1 December 2019.

Timeline

1 December 2017

Primary endpoint
1 December 2019

1 December 2019

Quick facts

Lead sponsor	University Hospital, Montpellier
Status	Completed
Study type	OBSERVATIONAL
Enrollment	400
Start date	1 December 2017
Primary completion	1 December 2019
Estimated completion	1 December 2019
Sites	1 location across France

Drugs / interventions tested

3D printing

Conditions studied

Atrial Fibrillation — all drugs for Atrial Fibrillation →

Sponsor

University Hospital, Montpellier

Who can join

18 and older, any sex, with Atrial Fibrillation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Left atrial appendage closure (LAAC) was approved by the ESC guidelines as a stroke prevention alternative to warfarin for patients with nonvalvular atrial fibrillation in patients at high risk of bleeding (IIbB). Although the overall LAAC benefice, in term of prevention of stroke or embolisme and decresing the anticoagulant-related risk of bleeding is already demonstrated, however the procedure success and safety, critically depends on understanding LAA anatomy and adequate pre-procedure planning. 3D-printed patient-specific adaptive and flexible LA models have demonstrated in a previous study an improving in LAAO device sizing, a better pre-procedural planning of the optimal trans-septal puncture site, by incorporating all anatomical variations and an improuving patient outcomes by reducing procedure time and number of prostheses employed per patient. This technique is now used in several surgical centers in France and large prospective evaluation of the practice is necessary.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

From ideas to long-term studies: 3D printing clinical trials review.
Witowski J, Sitkowski M, Zuzak T, Coles-Black J, et al · · 2018 · cited 39× · PMID 29790077 · DOI 10.1007/s11548-018-1793-8
Complex transcatheter left atrial appendage closure using a tailored trans-jugular approach simulated by 3D printing: a case report.
Ciobotaru V, Tadros VX, Martin CA, Hascoet S. · · 2022 · cited 5× · PMID 35965604 · DOI 10.1093/ehjcr/ytac304
Retro-Curve Access Sheath for Retroverted Anatomy in Left Atrial Appendage Closure: Bench Validation and Patient-Specific Simulation Study.
Ciobotaru V, Elbaz M, Iriart X, Bouisset F, et al · · 2026 · PMID 42016807 · DOI 10.1016/j.shj.2026.100820

Verify or expand the search:

Other trials of 3D printing

Trials testing the same drug.

NCT03348293 — Safety Study of 3D Printing Personalized Biodegradable Implant for Breast Reconstruction · Phase 1 · completed

Other recruiting trials for Atrial Fibrillation

Currently open trials in the same condition.

NCT07429214 — A Study of VARIPULSE Catheter and TRUPULSE Generator With VARIPULSE Pro Software in Participants With PAF or PsAF · NA · recruiting
NCT07271238 — Feasibility Study on the VERAFEYE Imaging and Navigation System for Guided Catheter Ablation Procedures · NA · recruiting
NCT07388108 — Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery. · recruiting
NCT07428967 — AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function · NA · recruiting
NCT06650995 — AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure · NA · recruiting

Other University Hospital, Montpellier trials

Trials by the same sponsor.

NCT07524127 — Phenotyping of Type 2 Inflammation Profile by Rheology of Nasal Secretions and Tissue Quantification of Eosinophilic Pol · NA · not yet recruiting
NCT07255495 — Effects of Neuromuscular Scoliosis Surgery on Nutritional Metabolism · NA · not yet recruiting
NCT07534189 — Prospective Cohort Study Evaluating a Thermal Spa Programme in Symptomatic Knee Osteoarthritis · NA · not yet recruiting
NCT07515638 — Immun4Cure Cohort of Autoimmune Diseases · not yet recruiting
NCT07406516 — Identification of Kinematic Variables Specific of Patellar Tendinopathy in Athletes at Risk · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03330210 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Montpellier
Last refreshed: 10 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03330210.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing