NCT03327909 (TAKE-HOLD) is a NA clinical trial of TAKE vs. HOLD in ESRD, sponsored by Stanford University.

Who is sponsoring NCT03327909?

NCT03327909 is sponsored by Stanford University.

What drugs are being tested in NCT03327909?

Interventions in NCT03327909: TAKE vs. HOLD.

What condition does NCT03327909 study?

NCT03327909 studies ESRD, Hemodialysis Complication, Blood Pressure.

Is NCT03327909 still recruiting?

NCT03327909 is currently completed. Last updated 23 August 2022.

Last reviewed 2022-08-23 · How we verify

NCT03327909: TAKE-HOLD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis

Completed NA Last updated 23 August 2022

What this trial tests

NA trial testing TAKE vs. HOLD in ESRD in 131 participants. Completed in 14 December 2019.

Timeline

16 July 2018

Primary endpoint
14 December 2019

14 December 2019

Quick facts

Lead sponsor	Stanford University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	131
Start date	16 July 2018
Primary completion	14 December 2019
Estimated completion	14 December 2019
Sites	2 locations across United States

Drugs / interventions tested

TAKE vs. HOLD

Conditions studied

ESRD — all drugs for ESRD →
Hemodialysis Complication — all drugs for Hemodialysis Complication →
Blood Pressure — all drugs for Blood Pressure →

Sponsor

Stanford University

Who can join

18 and older, any sex, with ESRD or Hemodialysis Complication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

For patients with kidney failure requiring hemodialysis treatment, sometimes the blood pressure will drop too low during dialysis. In an effort to prevent that from occurring, patients are frequently told to skip doses of their blood pressure medications. However, whether this actually prevents blood pressure drops during dialysis, and whether it may cause more uncontrolled high blood pressure is unknown. TAKE-HOLD will study the effect of taking or holding blood pressure medication on blood pressure for patients on hemodialysis.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Flythe JE, Chang TI, Gallagher MP, Lindley E, et al · · 2020 · cited 177× · PMID 32278617 · DOI 10.1016/j.kint.2020.01.046
Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis: A Cluster Randomized Trial.
Chang TI, Tatoian ET, Montez-Rath ME, Chertow GM. · · 2021 · cited 8× · PMID 35373003 · DOI 10.34067/kid.0001922021
In-Center Hemodialysis Symptom Burden: Differences Between Men and Women.
Parsons G, Liu S, Chang TI. · · 2024 · cited 1× · PMID 39247763 · DOI 10.1016/j.xkme.2024.100881

Verify or expand the search:

Other recruiting trials for ESRD

Currently open trials in the same condition.

NCT06913647 — Effect of Canagliflozin on Ultrafiltration & Fibrosis in Patients on Peritoneal Dialysis · Phase 2 · recruiting
NCT06366230 — Adding Urea to the Final Dialysis Fluid · Phase 1, PHASE2 · recruiting
NCT05339139 — SAfety of Regional Citrate Anticoagulation (SARCA Study) · Phase 3 · recruiting
NCT05434325 — TESTING -ON Post-Trial ObservatioNal Cohort Study · recruiting
NCT05309785 — Safety and Efficacy of Canagliflozin in Advanced CKD · Phase 4 · active not recruiting

Other Stanford University trials

Trials by the same sponsor.

NCT05945147 — Ketamine and Midazolam Infusions for CRPS: Feasibility Study · Phase 2 · withdrawn
NCT04225949 — Patients Understanding of PROM Graphs · NA · withdrawn
NCT06273098 — School-Based Bladder Health Intervention · NA · withdrawn
NCT04652635 — Management of Nailbed Injuries · NA · withdrawn
NCT05443503 — Stanford Spine Keeper - Managing Your Low Back Pain · NA · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03327909 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Stanford University
Last refreshed: 23 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03327909.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing