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NCT03326895: EPMCS-CA

A Prospective, Multi-Center Evaluation of the ECHELON CIRCULAR Powered Stapler in Left-Sided Colorectal Anastomoses

Completed NA Results posted Last updated 11 January 2021
What this trial tests

NA trial testing Left-sided colon resection in Left-sided Colon Resection in 168 participants. Completed in 15 January 2020.

Timeline
20 November 2017
Primary endpoint
6 December 2019
15 January 2020

Quick facts

Lead sponsorEthicon Endo-Surgery
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposetreatment
Enrollment168
Start date20 November 2017
Primary completion6 December 2019
Estimated completion15 January 2020
Sites12 locations across Belgium, United Kingdom, Germany, United States, Spain

Drugs / interventions tested

Conditions studied

Sponsor

Ethicon Endo-Surgery — full company profile →

Who can join

18 and older, any sex, with Left-sided Colon Resection. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Percentage of Participants With Stapler Performance Issues Primary · Intraoperative

A stapler performance issue is defined as a failure of the ECHELON CIRCULAR Powered Stapler to perform per its instructions for use. This includes but is not limited to difficulty placing or removing the stapler, stapler misfire/failure of the device to fully fire, staple line defects, incomplete or thin donuts, tissue damage, positive intraoperative leak test, detached components, unformed staples, or any other device failure.

GroupValue95% CI
ECHELON CIRCULAR Powered Stapler11.97.4 – 17.8
SURG-TLX Questionnaire Secondary · Collected postoperative for intraoperative stress

The Surgery Task Load index (SURG-TLX) questionnaire was completed by the participating surgeon following each procedure. The questionnaire was used to provide an assessment of surgical stress (surgeon) associated with the procedure (defined as the creation of the anastomosis). There are six specific components (mental, physical, temporal, task, situational, and distractions) that are used for evaluating the surgeon experience after each surgery is performed. Each component is scored on a 0 to 100 scale with lower scores representing a "low" response on that component and higher scores indica

Overall Score
GroupValue95% CI
ECHELON CIRCULAR Powered Stapler38.0± 21.60
Mental Demands (How mentally fatiguing was the procedure?)
GroupValue95% CI
ECHELON CIRCULAR Powered Stapler44.9± 27.8
Physical Demands (How physically fatiguing was the procedure?)
GroupValue95% CI
ECHELON CIRCULAR Powered Stapler37.9± 26.5
Temporal Demands (How hurried or rushed was the pace of the procedure?)
GroupValue95% CI
ECHELON CIRCULAR Powered Stapler30.3± 22.6
Task Complexity (How complex was the procedure?)
GroupValue95% CI
ECHELON CIRCULAR Powered Stapler50.3± 28.6
Situational Stress (How anxious did you feel while performing the procedure?)
GroupValue95% CI
ECHELON CIRCULAR Powered Stapler38.6± 27.3
Distractions (How distracting was the operating environment?)
GroupValue95% CI
ECHELON CIRCULAR Powered Stapler26.5± 21.0

Adverse events — posted to ClinicalTrials.gov

Time frame: 4 Weeks Post Procedure. Reporting threshold: 1.2%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

ECHELON CIRCULAR Powered Stapler
Serious: 13/168 (8%)
Deaths: 0/168

Serious adverse events (15 terms)

ReactionSystemECHELON CIRCULAR Powered S…
Gastrointestinal Stoma ComplicationInjury, poisoning and procedural complications
Anastomotic LeakInjury, poisoning and procedural complications
Pelvic AbscessInfections and infestations
Anastomotic StenosisInjury, poisoning and procedural complications
Incision Site PainInjury, poisoning and procedural complications
Post Procedural HemorrhageInjury, poisoning and procedural complications
Post-operative IleusInjury, poisoning and procedural complications
Stoma ComplicationInjury, poisoning and procedural complications
Stoma Site ErythemaInjury, poisoning and procedural complications
Urinary Tract InfectionInfections and infestations
Wound InfectionInfections and infestations
Abdominal PainGastrointestinal disorders
IleusGastrointestinal disorders
Large Intestinal ObstructionGastrointestinal disorders
C-reactive Protein IncreasedInvestigations
Other adverse events (11 terms — click to expand)

ReactionSystemECHELON CIRCULAR Powered S…
Abdominal PainGastrointestinal disorders
NauseaGastrointestinal disorders
VomitingGastrointestinal disorders
Procedural PainInjury, poisoning and procedural complications
Acute Kidney InjuryRenal and urinary disorders
PyrexiaGeneral disorders
HypotensionVascular disorders
ConstipationGastrointestinal disorders
DyspepsiaGastrointestinal disorders
Urinary RetentionRenal and urinary disorders
Oxygen Saturation DecreasedInvestigations

Most-reported serious reactions: Gastrointestinal Stoma Complication, Anastomotic Leak, Pelvic Abscess, Anastomotic Stenosis, Incision Site Pain, Post Procedural Hemorrhage, Post-operative Ileus, Stoma Complication.

Data from ClinicalTrials.gov NCT03326895 adverse events section.

Sponsor's own description

This prospective clinical study will evaluate the intra-operative performance of the powered circular stapler used in left colectomy procedures in a post-market setting.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Outcomes associated with the use of a new powered circular stapler for left-sided colorectal reconstructions: a propensity score matching-adjusted indirect comparison with manual circular staplers.
    Sylla P, Sagar P, Johnston SS, Dwarakanathan HR, et al · · 2022 · cited 25× · PMID 34031743 · DOI 10.1007/s00464-021-08542-7
  2. Indirect comparison between powered and manual circular staplers for left-sided colorectal anastomoses: clinical and economic outcomes in China.
    Bai J, Zhao Y, Liang H, Li J, et al · · 2022 · cited 4× · PMID 36045434 · DOI 10.1186/s12962-022-00380-1

Verify or expand the search:

Other recruiting trials for Left-sided Colon Resection

Currently open trials in the same condition.

Other Ethicon Endo-Surgery trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03326895.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing