NCT03323580 is a NA clinical trial of GDFT in Fluid Therapy, sponsored by Beijing Tiantan Hospital.

Who is sponsoring NCT03323580?

NCT03323580 is sponsored by Beijing Tiantan Hospital.

What drugs are being tested in NCT03323580?

Interventions in NCT03323580: GDFT, traditional fluid therapy.

What condition does NCT03323580 study?

NCT03323580 studies Fluid Therapy, Brain Edema, Brain Tumor.

Is NCT03323580 still recruiting?

NCT03323580 is currently completed. Last updated 24 March 2023.

Last reviewed 2023-03-24 · How we verify

NCT03323580

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Intraoperative GDFT on the Postoperative Brain Edema

Completed NA Last updated 24 March 2023

What this trial tests

NA trial testing GDFT in Fluid Therapy in 480 participants. Completed in 31 October 2022.

Timeline

26 November 2018

Primary endpoint
21 September 2022

31 October 2022

Quick facts

Lead sponsor	Beijing Tiantan Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	supportive care
Enrollment	480
Start date	26 November 2018
Primary completion	21 September 2022
Estimated completion	31 October 2022
Sites	1 location across China

Drugs / interventions tested

GDFT
traditional fluid therapy

Conditions studied

Fluid Therapy — all drugs for Fluid Therapy →
Brain Edema — all drugs for Brain Edema →
Brain Tumor — all drugs for Brain Tumor →

Sponsor

Beijing Tiantan Hospital

Who can join

Adults 18 to 65, any sex, with Fluid Therapy or Brain Edema. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain. To our knowledge, there has been no extensive and quantitative analysis of brain edema following SVV-based GDFT in neurosurgical patients with malignant supratentorial glioma. So the study aims to observe the effect of the stroke volume variation-based GDFT on the postoperative brain edema and decrease the incidence of postoperative complications in neurosurgical patients with malignant supratentorial gliomas.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Effect of intraoperative goal-directed fluid therapy on the postoperative brain edema in patients undergoing high-grade glioma resections: a study protocol of randomized control trial.
Liu X, Zhang X, Fan Y, Li S, et al · · 2022 · cited 3× · PMID 36401274 · DOI 10.1186/s13063-022-06859-9
Intraoperative goal-directed fluid management and postoperative brain edema in patients having high-grade gliomas resections: a randomized trial.
Liu X, Zhang X, Fan Y, Wang B, et al · · 2025 · cited 1× · PMID 39037734 · DOI 10.1097/js9.0000000000001969
Effect of Intraoperative Goal-directed Fluid Therapy on the Postoperative Brain Edema in Patients undergoing High-Grade Gliomas Resections: a study protocol of randomized control trial
Liu X, Zhang X, Fan Y, Li S, et al · · 2022 · DOI 10.21203/rs.3.rs-1310950/v1

Verify or expand the search:

Other trials of GDFT

Trials testing the same drug.

NCT04092608 — Restrictive vs Goal Directed Fluid Therapy During Hepatobiliary Surgery · NA · completed
NCT06810648 — Epidural Analgesia and Intraoperative Fluid Management in Colorectal Surgery · NA · completed

Other recruiting trials for Fluid Therapy

Currently open trials in the same condition.

NCT07260890 — Paired Comparison of SVV and PVI Accuracy · recruiting
NCT07522580 — Fluid-responsiveness Assessment Simplified by Electric Cardiometry in Children · recruiting
NCT07255469 — Metabolic Fluid Responsiveness in Children · recruiting
NCT06396884 — Hemodynamic Optimization During Spinal Anesthesia in the Elderly · recruiting
NCT06206434 — Point of Care Ultrasound and Co-loading in Patients With Spinal-induced Hypotension and Cardiac Diseases · recruiting

Other Beijing Tiantan Hospital trials

Trials by the same sponsor.

NCT07341854 — Dexamethasone Palmitate for Postoperative Pain · NA · not yet recruiting
NCT07527013 — Stratified Blood Pressure Management Strategy After Endovascular Treatment for Acute Ischemic Stroke · Phase 3 · not yet recruiting
NCT07520370 — Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor · NA · not yet recruiting
NCT07526987 — Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis · Phase 3 · not yet recruiting
NCT07591207 — The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03323580 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Beijing Tiantan Hospital
Last refreshed: 24 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03323580.

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