Who is sponsoring NCT03322774?

NCT03322774 is sponsored by Henry Ford Health System.

What drugs are being tested in NCT03322774?

Interventions in NCT03322774: digital Cognitive Behavioral Therapy for Insomnia, face-to-face Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education Control.

What condition does NCT03322774 study?

NCT03322774 studies Insomnia, Primary, Major Depressive Disorder, Rumination.

Is NCT03322774 still recruiting?

NCT03322774 is currently completed. Last updated 1 October 2024.

Last reviewed 2024-10-01 · How we verify

NCT03322774: STRIDE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Sleep To Reduce Incident Depression Effectively

Completed NA Last updated 1 October 2024

What this trial tests

NA trial testing digital Cognitive Behavioral Therapy for Insomnia in Insomnia, Primary in 1,237 participants. Completed in 27 June 2024.

Timeline

9 March 2018

Primary endpoint
30 April 2023

27 June 2024

Quick facts

Lead sponsor	Henry Ford Health System
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	single
Primary purpose	prevention
Enrollment	1,237
Start date	9 March 2018
Primary completion	30 April 2023
Estimated completion	27 June 2024
Sites	1 location across United States

Drugs / interventions tested

digital Cognitive Behavioral Therapy for Insomnia
face-to-face Cognitive Behavioral Therapy for Insomnia
Sleep Hygiene Education Control

Conditions studied

Insomnia, Primary — all drugs for Insomnia, Primary →
Major Depressive Disorder — all drugs for Major Depressive Disorder →
Rumination — all drugs for Rumination →

Sponsor

Henry Ford Health System — full company profile →

Who can join

18 and older, any sex, with Insomnia, Primary or Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This project will assess the effectiveness of a stepped-care model (i.e. digital Cognitive Behavioral Therapy for Insomnia (dCBT-I) followed by face-to-face CBT-I) in improving severity of insomnia and sleep outcomes in an insomnia cohort. This project will also investigate the effectiveness of this stepped-care model in prevention of major depressive disorder, and will test rumination as a mediator of treatment response.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Sleep to Reduce Incident Depression Effectively (STRIDE): study protocol for a randomized controlled trial comparing stepped-care cognitive-behavioral therapy for insomnia versus sleep education control to prevent major depression.
Drake CL, Kalmbach DA, Cheng P, Ahmedani BK, et al · · 2022 · cited 7× · PMID 36457045 · DOI 10.1186/s13063-022-06850-4
Sleep to Reduce Incident Depression Effectively (STRIDE): Study protocol for a randomized controlled trial comparing stepped-care cognitive behavioral therapy for insomnia versus sleep education control to prevent major depression.
Drake CL, Kalmbach DA, Cheng P, Ahmedani BK, et al · · 2022 · cited 1× · DOI 10.21203/rs.3.rs-1946557/v1
Prevention of Pain Interference in Insomnia Patients via Digital Cognitive-Behavioral Therapy for Insomnia.
Jennings MB, Kalmbach DA, Reffi AN, Miller CB, et al · · 2025 · PMID 40324067 · DOI 10.1080/15402002.2025.2500519

Verify or expand the search:

Other recruiting trials for Insomnia, Primary

Currently open trials in the same condition.

NCT06767137 — Comparative Efficacy of BRT and CBT-I for Insomnia · NA · recruiting
NCT06281756 — Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia · EARLY_PHASE1 · recruiting
NCT04953559 — Transcranial Magnetic Stimulation of the Default Mode Network to Improve Sleep · NA · recruiting
NCT03109210 — Therapist-Directed VS Online Therapy for Insomnia Co-Occuring With Sleep Apnea · NA · active not recruiting

Other Henry Ford Health System trials

Trials by the same sponsor.

NCT07450183 — Perioperative Cemiplimab for Resectable Non-Small Cell Lung Cancer With High PD-L1 · Phase 2 · not yet recruiting
NCT07418853 — Comparison of Goniotomy Device Outcomes in Combined Phacoemulsification-goniotomy Surgeries · NA · not yet recruiting
NCT06670287 — The Use of Multiple Sensors to Track Sleep in Nightshift Workers · NA · recruiting
NCT07363525 — Michigan Initial Experience Using Tigertriever for Thrombectomy · not yet recruiting
NCT07530172 — Radioembolization Versus External Radiation Therapy · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03322774 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Henry Ford Health System
Last refreshed: 1 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03322774.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing