NCT03279198: COBRA

Increasing Colorectal and Breast Cancer Screening in Women

Completed NA Last updated 12 September 2017

What this trial tests

NA trial testing TIWeb in Breast Cancer Female in 1,196 participants. Completed in 31 May 2017.

Timeline

22 July 2010

Primary endpoint
15 September 2015

31 May 2017

Quick facts

Lead sponsor	Indiana University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	none
Primary purpose	prevention
Enrollment	1,196
Start date	22 July 2010
Primary completion	15 September 2015
Estimated completion	31 May 2017

Drugs / interventions tested

• TIWeb
• CSC
• UC
• TIWeb+CSC

Conditions studied

• Breast Cancer Female — all drugs for Breast Cancer Female →
• Colorectal Cancer — all drugs for Colorectal Cancer →

Sponsor

Indiana University

Who can join

Adults 50 to 75, female only, with Breast Cancer Female or Colorectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study compares the efficacy (adherence and stage) of four interventions to promote colorectal (CRC) and breast cancer (BC) screenings among women ages 50 to 75. They are:

1. usual care;
2. a TIWeb (tailored intervention Website)
3. a CSC (cancer screening call) and
4. TIWeb + a CSC. This study also compares the cost-effectiveness of the 4 interventions to promote CRC and BC screening among women ages 50 to 75.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. A Randomized Trial to Compare a Tailored Web-Based Intervention and Tailored Phone Counseling to Usual Care for Increasing Colorectal Cancer Screening.
   Champion VL, Christy SM, Rakowski W, Gathirua-Mwangi WG, et al · · 2018 · cited 28× · PMID 30181203 · DOI 10.1158/1055-9965.epi-18-0180
2. An RCT to Increase Breast and Colorectal Cancer Screening.
   Champion VL, Christy SM, Rakowski W, Lairson DR, et al · · 2020 · cited 24× · PMID 32690203 · DOI 10.1016/j.amepre.2020.03.008
3. Impact of Tailored Interventions on Receipt of a Preference-Concordant Colorectal Cancer Screening Test.
   Christy SM, Monahan PO, Stump TE, Rawl SM, et al · · 2020 · cited 7× · PMID 31814511 · DOI 10.1177/0272989x19890603
4. Economic Evaluation of Tailored Web versus Tailored Telephone-Based Interventions to Increase Colorectal Cancer Screening among Women.
   Lairson DR, Chung TH, Huang D, Stump TE, et al · · 2020 · cited 3× · PMID 31969343 · DOI 10.1158/1940-6207.capr-19-0376
5. Economic Evaluation of Web- versus Telephone-based Interventions to Simultaneously Increase Colorectal and Breast Cancer Screening Among Women.
   Huang D, Lairson DR, Chung TH, Monahan PO, et al · · 2021 · cited 2× · PMID 34244154 · DOI 10.1158/1940-6207.capr-21-0009