NCT03275168

Developing a Dyadic Intervention for Sexually Transmitted Infection (STI)/HIV Prevention in Youth

Completed NA Results posted Last updated 9 December 2025

What this trial tests

NA trial testing Intervention in Exposure to Sexually Transmissible Disorder (Event) in 68 participants. Completed in 1 October 2021.

Timeline

15 January 2018

Primary endpoint
1 October 2021

1 October 2021

Quick facts

Lead sponsor	Johns Hopkins University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	68
Start date	15 January 2018
Primary completion	1 October 2021
Estimated completion	1 October 2021
Sites	1 location across United States

Drugs / interventions tested

• Intervention
• Individual evidence-based STI/HIV prevention intervention

Conditions studied

• Exposure to Sexually Transmissible Disorder (Event) — all drugs for Exposure to Sexually Transmissible Disorder (Event) →

Sponsor

Johns Hopkins University

Who can join

Adults 16 to 30, any sex, with Exposure to Sexually Transmissible Disorder (Event). Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Feasibility as Assessed by the Number of Participants Who Are Enrolled With a Partner Primary · 24 months

Recruitment (as a measure of feasibility) will be assessed by calculating the number of eligible patients who return with a partner to the study appointment and consent to participate in the study.

Group	Value	95% CI
Control	17
Intervention	17

Acceptability as Assessed by Number of Participants Available for Week 6-8 Interview Secondary · 6-8 weeks

Retention for the 6-8 week interview will also be calculated as a measure of acceptability.

Group	Value	95% CI
Control	27
Intervention	25

Sponsor's own description

This pilot project will evaluate the feasibility, acceptability, and preliminary effectiveness of a couples-based behavioral intervention \[COUPLES\] that augments individual evidence-based interventions with joint health education counseling for STI-affected AYA dyads within a primary care setting.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Social Media Versus Traditional Clinic-Based Recruitment for a Dyadic Sexually Transmitted Infection Prevention Trial: Results From the Sexperience Study.
   Woods C, Yusuf H, Matson P, Marcell AV, et al · · 2021 · cited 7× · PMID 33867231 · DOI 10.1016/j.jadohealth.2021.03.004
2. Understanding Perceived Risks and Sexual Behavior Among Adolescents and Young Adults During the COVID-19 Pandemic.
   Trent M, Perin J, Yusuf H, Agwu A, et al · · 2023 · cited 5× · PMID 36669959 · DOI 10.1016/j.jadohealth.2022.11.249
3. Dyadic Intervention for Sexually Transmitted Infection Prevention in Urban Adolescents and Young Adults (The SEXPERIENCE Study): Protocol for a Randomized Controlled Trial.
   Trent M, Yusuf HE, Rowell J, Toppins J, et al · · 2022 · cited 4× · PMID 35612881 · DOI 10.2196/29389