NCT03270553 is a Phase 1 clinical trial of plazomicin in Healthy Volunteers, sponsored by Achaogen, Inc..

Who is sponsoring NCT03270553?

NCT03270553 is sponsored by Achaogen, Inc..

What drugs are being tested in NCT03270553?

Interventions in NCT03270553: plazomicin, metformin.

What condition does NCT03270553 study?

NCT03270553 studies Healthy Volunteers.

Is NCT03270553 still recruiting?

NCT03270553 is currently completed. Last updated 11 October 2017.

Last reviewed 2017-10-11 · How we verify

NCT03270553

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Study to Assess the Effect of Plazomicin on the Pharmacokinetics of Metformin

Completed Phase 1 Last updated 11 October 2017

What this trial tests

Phase 1 trial testing plazomicin in Healthy Volunteers in 16 participants. Completed in 7 October 2017.

Timeline

31 August 2017

Primary endpoint
7 October 2017

7 October 2017

Quick facts

Lead sponsor	Achaogen, Inc.
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	16
Start date	31 August 2017
Primary completion	7 October 2017
Estimated completion	7 October 2017
Sites	1 location across United States

Drugs / interventions tested

plazomicin — full drug profile →
metformin (metformin) — full drug profile →

Conditions studied

Healthy Volunteers — all drugs for Healthy Volunteers →

Sponsor

Achaogen, Inc. — full company profile →

Who can join

Adults 19 to 55, any sex, with Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a single-center, Phase 1, open label, randomized, two-sequence, two-period, crossover study to evaluate the drug-drug interaction potential between plazomicin and metformin in healthy subjects.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Plazomicin: a new aminoglycoside in the fight against antimicrobial resistance.
Clark JA, Burgess DS. · · 2020 · cited 40× · PMID 32953108 · DOI 10.1177/2049936120952604
Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review.
Alfieri A, Di Franco S, Donatiello V, Maffei V, et al · · 2022 · cited 21× · PMID 36556314 · DOI 10.3390/life12121949
No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects.
Choi T, Komirenko AS, Riddle V, Kim A, et al · · 2019 · cited 7× · PMID 30605260 · DOI 10.1002/cpdd.648

Verify or expand the search:

Other trials of plazomicin

Trials testing the same drug.

NCT02486627 — A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including · Phase 3 · completed
NCT01970371 — A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae ( · Phase 3 · completed
NCT01096849 — A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acu · Phase 2 · completed

Other recruiting trials for Healthy Volunteers

Currently open trials in the same condition.

NCT07504003 — Influence of Training Session Duration on Improvements in Physiological Resilience to Exercise · NA · recruiting
NCT07446400 — A Trial to Examine the Interaction of Repinatrabit With Ethinyl Estradiol/Norethindrone, Metformin,Carbamazepine, Rosuva · Phase 1 · recruiting
NCT07495813 — A Study to See How RO7763505 Works and How Safe it is When Given to Healthy People and People With Stable Heart Disease · Phase 1 · recruiting
NCT07499050 — A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity · Phase 1 · recruiting
NCT07342114 — A Dose-Escalation Study of RO7875913 in Healthy Participants · Phase 1 · recruiting

Other Achaogen, Inc. trials

Trials by the same sponsor.

NCT03177278 — A Study to Assess the Metabolism, Excretion, and Mass Balance of Radio-Labeled Plazomicin · Phase 1 · completed
NCT03163550 — A Study to Assess the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interaction Potential of ACHN-3 · Phase 1 · completed
NCT02486627 — A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including · Phase 3 · completed
NCT01970371 — A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae ( · Phase 3 · completed
NCT01096849 — A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acu · Phase 2 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03270553 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Achaogen, Inc.
Last refreshed: 11 October 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03270553.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing