NCT03266965 is a Phase 1 clinical trial of Carbidopa in Multiple Sclerosis, sponsored by University of Miami.

Who is sponsoring NCT03266965?

NCT03266965 is sponsored by University of Miami.

What drugs are being tested in NCT03266965?

Interventions in NCT03266965: Carbidopa, L-Histidine.

What condition does NCT03266965 study?

NCT03266965 studies Multiple Sclerosis.

Is NCT03266965 still recruiting?

NCT03266965 is currently completed. Last updated 8 October 2020.

Last reviewed 2020-10-08 · How we verify

NCT03266965

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Histaminergic Basis of Central Fatigue in Multiple Sclerosis - A Novel Approach

Completed Phase 1 Last updated 8 October 2020

What this trial tests

Phase 1 trial testing Carbidopa in Multiple Sclerosis in 18 participants. Completed in 7 August 2020.

Timeline

23 March 2018

Primary endpoint
7 August 2020

7 August 2020

Quick facts

Lead sponsor	University of Miami
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	18
Start date	23 March 2018
Primary completion	7 August 2020
Estimated completion	7 August 2020
Sites	1 location across United States

Drugs / interventions tested

Carbidopa (CARBIDOPA) — full drug profile →
L-Histidine — full drug profile →

Conditions studied

Multiple Sclerosis — all drugs for Multiple Sclerosis →

Sponsor

University of Miami

Who can join

Adults 18 to 60, any sex, with Multiple Sclerosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The histaminergic system is phylogenetically one of the oldest parts of the nervous system but it is a relatively recent discovery. It is involved with several vegetative functions like sleep, attention and learning, feeding and satiety, working memory, cognition, depression, and most of all arousal and energy

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Seasonal Changes in Serum Metabolites in Multiple Sclerosis Relapse.
Martynova E, Khaibullin T, Salafutdinov I, Markelova M, et al · · 2023 · cited 10× · PMID 36834957 · DOI 10.3390/ijms24043542
Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases.
Lee D, Smith LEH. · · 2024 · cited 4× · PMID 39768274 · DOI 10.3390/life14121566

Verify or expand the search:

Other trials of Carbidopa

Trials testing the same drug.

NCT04520178 — Effects of 5HTP on the Injured Human Spinal Cord · Phase 2, PHASE3 · recruiting
NCT04000919 — Effects of 5HTP and LDOPA on CNS Excitability After SCI · Phase 2, PHASE3 · suspended
NCT03115827 — Norepinephrine-targeted Therapy for Action Control in Parkinson Disease · Phase 4 · completed
NCT03055936 — Dose-finding Pharmacokinetic Study in Healthy Males · Phase 1 · completed
NCT00845000 — Acute Effects of Preladenant (SCH 420814) on Dyskinesia and Parkinsonism in Levodopa Treated Participants (P05550) · Phase 1 · completed

Other recruiting trials for Multiple Sclerosis

Currently open trials in the same condition.

NCT07507084 — The Effect of Internal- or External-Focused Exercise Training, Administered in Conjunction With a Cognitive Task, on Wal · NA · recruiting
NCT07524231 — Evaluation of the Effects of Laughter Yoga · NA · recruiting
NCT07489794 — URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS · recruiting
NCT07236684 — Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity · recruiting
NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Other University of Miami trials

Trials by the same sponsor.

NCT06003712 — Exploring the Effect of Mindfulness on Quality of Life (QoL) in Spinal Cord Injury (SCI) · NA · not yet recruiting
NCT06077071 — MRIdian "RADAR" Trial · NA · not yet recruiting
NCT07472413 — Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot Project · Phase 3 · not yet recruiting
NCT07322289 — Antibiotic-coated Braided Suture Study · NA · not yet recruiting
NCT07469592 — eHealth Mindfulness-based Music Therapy Intervention for Patients Undergoing Stem Cell Transplantation · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03266965 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Miami
Last refreshed: 8 October 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03266965.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing