NCT03248908 (PUP-AIT) is a NA clinical trial of Pupillary dilation reflex in Pain, Acute, sponsored by University Hospital, Antwerp.

Who is sponsoring NCT03248908?

NCT03248908 is sponsored by University Hospital, Antwerp.

What drugs are being tested in NCT03248908?

Interventions in NCT03248908: Pupillary dilation reflex, Standard of care.

What condition does NCT03248908 study?

NCT03248908 studies Pain, Acute, Anesthesia.

Is NCT03248908 still recruiting?

NCT03248908 is currently completed. Last updated 15 May 2023.

Last reviewed 2023-05-15 · How we verify

NCT03248908: PUP-AIT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pupillary Dilation Reflex Assessment for Intraoperative Analgesic Titration.

Completed NA Last updated 15 May 2023

What this trial tests

NA trial testing Pupillary dilation reflex in Pain, Acute in 120 participants. Completed in 31 January 2022.

Timeline

12 October 2017

Primary endpoint
6 September 2021

31 January 2022

Quick facts

Lead sponsor	University Hospital, Antwerp
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	120
Start date	12 October 2017
Primary completion	6 September 2021
Estimated completion	31 January 2022
Sites	1 location across Belgium

Drugs / interventions tested

Pupillary dilation reflex
Standard of care

Conditions studied

Pain, Acute — all drugs for Pain, Acute →
Anesthesia — all drugs for Anesthesia →

Sponsor

University Hospital, Antwerp

Who can join

18 and older, any sex, with Pain, Acute or Anesthesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this double blinded randomized controlled study, the pupillary dilation reflex is used for as a nociceptive indicator for opioid administration during elective surgery under general anesthesia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Pupillary reflex dilation and pain index evaluation during general anesthesia using sufentanil: a double-blind randomized controlled trial.
Vlaenderen DV, Hans G, Saldien V, Wildemeersch D. · · 2022 · cited 5× · PMID 36189668 · DOI 10.2217/pmt-2022-0027

Verify or expand the search:

Other recruiting trials for Pain, Acute

Currently open trials in the same condition.

NCT07249827 — A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guid · Phase 2 · recruiting
NCT07053774 — Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain · Phase 2 · recruiting
NCT07009951 — Impact of Virtual Reality in Cardiac Electrophysiology · recruiting
NCT06960317 — Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements · NA · recruiting
NCT06754657 — CORA-Q15: Continuous vs. Single-injection Interscalene Block on QoR-15 in Outpatient Rotator Cuff Surgery · Phase 4 · recruiting

Other University Hospital, Antwerp trials

Trials by the same sponsor.

NCT07455422 — A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurr · NA · not yet recruiting
NCT07020715 — A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis · Phase 2 · not yet recruiting
NCT07443761 — Patients Undergoing Pancreatic Surgery at the Antwerp University Hospital. · active not recruiting
NCT06372847 — DISE-HNS Effect Study · NA · recruiting
NCT07189091 — CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03248908 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Antwerp
Last refreshed: 15 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03248908.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing