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NCT03247023
Long Term Follow-up of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement
trial testing Implantation of Integra Cadence Total Ankle Sysyem in Degenerative Arthritis in 61 participants. Terminated before completion.
8 December 2021
Quick facts
| Lead sponsor | Smith & Nephew, Inc. |
|---|---|
| Status | Terminated |
| Study type | OBSERVATIONAL |
| Enrollment | 61 |
| Start date | 18 September 2017 |
| Primary completion | 8 December 2021 |
| Estimated completion | 6 September 2023 |
| Sites | 6 locations across France, Belgium, United Kingdom, Canada, Spain |
Drugs / interventions tested
- Implantation of Integra Cadence Total Ankle Sysyem
Conditions studied
- Degenerative Arthritis — all drugs for Degenerative Arthritis →
- Rheumatoid Arthritis — all drugs for Rheumatoid Arthritis →
- Traumatic Arthritis — all drugs for Traumatic Arthritis →
Sponsor
Smith & Nephew, Inc. — full company profile →
Who can join
18 and older, any sex, with Degenerative Arthritis or Rheumatoid Arthritis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will evaluate the long term performance and safety data for the Cadence™ Total Ankle System (CTAS) when used for primary arthroplasty in patients with primary arthritis (e.g. degenerative disease), secondary arthritis (e.g. post-traumatic, avascular necrosis, if minimally 2/3 of the talus is preserved), and systemic arthritis of the ankle (e.g. rheumatoid arthritis, hemochromatosis)
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03247023
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Smith & Nephew, Inc. trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03247023 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Smith & Nephew, Inc.
- Last refreshed: 4 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03247023.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing