NCT06700850 is a NA clinical trial of Prototype dressing rectangle in Healthy, sponsored by Smith & Nephew, Inc..

Who is sponsoring NCT06700850?

NCT06700850 is sponsored by Smith & Nephew, Inc..

What drugs are being tested in NCT06700850?

Interventions in NCT06700850: Prototype dressing rectangle, Marketed dressing rectangle, Prototype dressing square, Marketed dressing square.

Is NCT06700850 still recruiting?

NCT06700850 is currently completed. Last updated 2 April 2026.

Are results published for NCT06700850?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2026-04-02 · How we verify

NCT06700850

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Human Participant Study of Prototype Non-medicated Multilayer Foam Dressings on Intact Skin

Completed NA Results posted Last updated 2 April 2026

What this trial tests

NA trial testing Prototype dressing rectangle in Healthy in 135 participants. Completed in 21 January 2025.

Timeline

28 October 2024

Primary endpoint
21 January 2025

21 January 2025

Quick facts

Lead sponsor	Smith & Nephew, Inc.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	none
Primary purpose	other
Enrollment	135
Start date	28 October 2024
Primary completion	21 January 2025
Estimated completion	21 January 2025
Sites	1 location across Germany

Drugs / interventions tested

Prototype dressing rectangle
Marketed dressing rectangle
Prototype dressing square
Marketed dressing square

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

Smith & Nephew, Inc. — full company profile →

Who can join

Adults 22 to 70, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Participants With Acceptable Dressing Presence at Day 7 Primary · Day 7

Count of participants with acceptable dressing presence was determined from a yes/no assessment at day 7, with a 'yes' response defined as the dressing is in place with no border lift reaching the pad and no pad exposure.

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	48
Marketed Dressing (Rectangle) on Knee	23
Prototype Dressing (Square) on Thigh	35
Marketed Dressing (Square) on Thigh	27
Prototype Dressing (Rectangle) on Knee	87
Marketed Dressing (Rectangle) on Knee	112
Prototype Dressing (Square) on Thigh	100
Marketed Dressing (Square) on Thigh	108

Acceptable Dressing Presence at Day 1 and Day 3 Secondary · Day 1 and Day 3

Count of participants with an acceptable dressing presence was determined from a yes/no assessment at Day 1 and 3, with a 'yes' response defined as the dressing is in place with no border lift reaching the pad and no pad exposure.

Day 1: Acceptable dressing presence

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	16
Marketed Dressing (Rectangle) on Knee	4
Prototype Dressing (Square) on Thigh	7
Marketed Dressing (Square) on Thigh	6
Prototype Dressing (Rectangle) on Knee	111
Marketed Dressing (Rectangle) on Knee	123
Prototype Dressing (Square) on Thigh	120
Marketed Dressing (Square) on Thigh	121

Day 3: Acceptable dressing presence

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	29
Marketed Dressing (Rectangle) on Knee	12
Prototype Dressing (Square) on Thigh	14
Marketed Dressing (Square) on Thigh	11
Prototype Dressing (Rectangle) on Knee	98
Marketed Dressing (Rectangle) on Knee	115
Prototype Dressing (Square) on Thigh	113
Marketed Dressing (Square) on Thigh	116

Presence of Dressing Secondary · Day 1, Day 3 and Day 7

Dressing presence was measured by the count of participants at Day 1, 3 and 7 based on responses to the question "Is the dressing in place?" (yes/no).

Day 1: Is the dressing in place?

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	0
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	1
Marketed Dressing (Square) on Thigh	2
Prototype Dressing (Rectangle) on Knee	127
Marketed Dressing (Rectangle) on Knee	127
Prototype Dressing (Square) on Thigh	126
Marketed Dressing (Square) on Thigh	125

Day 3: Is the dressing in place?

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	3
Marketed Dressing (Rectangle) on Knee	2
Prototype Dressing (Square) on Thigh	3
Marketed Dressing (Square) on Thigh	5
Prototype Dressing (Rectangle) on Knee	124
Marketed Dressing (Rectangle) on Knee	125
Prototype Dressing (Square) on Thigh	124
Marketed Dressing (Square) on Thigh	122

Day 7: Is the dressing in place?

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	6
Marketed Dressing (Rectangle) on Knee	3
Prototype Dressing (Square) on Thigh	7
Marketed Dressing (Square) on Thigh	9
Prototype Dressing (Rectangle) on Knee	121
Marketed Dressing (Rectangle) on Knee	124
Prototype Dressing (Square) on Thigh	120
Marketed Dressing (Square) on Thigh	118

Pad Integrity Secondary · Day 1, Day 3 and Day 7

Changes to the integrity of the dressing pad (e.g., bunching, folding, ridges) assessed at Day 1, 3 and 7 by count of participants categorized as one of the following: 1. 0% (no change) 2. 1-25% 3. 26%-50% 4. 51%-75% 5. 76-100% 6. Dressing missing

Day 1: Pad integrity

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	119
Marketed Dressing (Rectangle) on Knee	125
Prototype Dressing (Square) on Thigh	123
Marketed Dressing (Square) on Thigh	122
Prototype Dressing (Rectangle) on Knee	8
Marketed Dressing (Rectangle) on Knee	2
Prototype Dressing (Square) on Thigh	3
Marketed Dressing (Square) on Thigh	3
Prototype Dressing (Rectangle) on Knee	0
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0
Prototype Dressing (Rectangle) on Knee	0
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0

Day 3: Pad integrity

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	112
Marketed Dressing (Rectangle) on Knee	120
Prototype Dressing (Square) on Thigh	120
Marketed Dressing (Square) on Thigh	121
Prototype Dressing (Rectangle) on Knee	9
Marketed Dressing (Rectangle) on Knee	3
Prototype Dressing (Square) on Thigh	4
Marketed Dressing (Square) on Thigh	1
Prototype Dressing (Rectangle) on Knee	3
Marketed Dressing (Rectangle) on Knee	2
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0
Prototype Dressing (Rectangle) on Knee	0
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0

Day 7: Pad integrity

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	82
Marketed Dressing (Rectangle) on Knee	108
Prototype Dressing (Square) on Thigh	94
Marketed Dressing (Square) on Thigh	101
Prototype Dressing (Rectangle) on Knee	35
Marketed Dressing (Rectangle) on Knee	13
Prototype Dressing (Square) on Thigh	22
Marketed Dressing (Square) on Thigh	15
Prototype Dressing (Rectangle) on Knee	3
Marketed Dressing (Rectangle) on Knee	3
Prototype Dressing (Square) on Thigh	1
Marketed Dressing (Square) on Thigh	1
Prototype Dressing (Rectangle) on Knee	1
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	3
Marketed Dressing (Square) on Thigh	1

Pad Lift Secondary · Day 1, Day 3 and Day 7

Pad lift to determine the extent of pad area lifted and if it was no longer adhered to the participant's skin was identified at Day 1, 3 and 7. Lifting of the dressing pad was measured by the count of participants from one of the following percentage pad lift categories: 1. 0% (no lift) 2. 1-25% 3. 26%-50% 4. 51%-75% 5. 76-100% 6. Dressing missing

Day 1: Pad lift

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	113
Marketed Dressing (Rectangle) on Knee	123
Prototype Dressing (Square) on Thigh	121
Marketed Dressing (Square) on Thigh	121
Prototype Dressing (Rectangle) on Knee	13
Marketed Dressing (Rectangle) on Knee	3
Prototype Dressing (Square) on Thigh	5
Marketed Dressing (Square) on Thigh	4
Prototype Dressing (Rectangle) on Knee	1
Marketed Dressing (Rectangle) on Knee	1
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0
Prototype Dressing (Rectangle) on Knee	0
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0

Day 3: Pad lift

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	99
Marketed Dressing (Rectangle) on Knee	117
Prototype Dressing (Square) on Thigh	114
Marketed Dressing (Square) on Thigh	117
Prototype Dressing (Rectangle) on Knee	21
Marketed Dressing (Rectangle) on Knee	5
Prototype Dressing (Square) on Thigh	9
Marketed Dressing (Square) on Thigh	5
Prototype Dressing (Rectangle) on Knee	4
Marketed Dressing (Rectangle) on Knee	3
Prototype Dressing (Square) on Thigh	1
Marketed Dressing (Square) on Thigh	0
Prototype Dressing (Rectangle) on Knee	0
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0

Day 7: Pad lift

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	86
Marketed Dressing (Rectangle) on Knee	111
Prototype Dressing (Square) on Thigh	95
Marketed Dressing (Square) on Thigh	105
Prototype Dressing (Rectangle) on Knee	29
Marketed Dressing (Rectangle) on Knee	10
Prototype Dressing (Square) on Thigh	20
Marketed Dressing (Square) on Thigh	11
Prototype Dressing (Rectangle) on Knee	5
Marketed Dressing (Rectangle) on Knee	3
Prototype Dressing (Square) on Thigh	2
Marketed Dressing (Square) on Thigh	2
Prototype Dressing (Rectangle) on Knee	1
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	3
Marketed Dressing (Square) on Thigh	0

Border Lift Secondary · Day 1, Day 3 and Day 7

Border lift to determine the extent of border area lifted and if it was no longer adhered to the participant's skin was identified at Day 1, 3 and 7. Lifting of the dressing border was measured by the count of participants from one of the following percentage border lift categories: 1. 0% (no lift) 2. 1-25% 3. 26%-50% 4. 51%-75% 5. 76-100% 6. Dressing missing

Day 1: Border lift

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	36
Marketed Dressing (Rectangle) on Knee	63
Prototype Dressing (Square) on Thigh	66
Marketed Dressing (Square) on Thigh	74
Prototype Dressing (Rectangle) on Knee	87
Marketed Dressing (Rectangle) on Knee	62
Prototype Dressing (Square) on Thigh	57
Marketed Dressing (Square) on Thigh	47
Prototype Dressing (Rectangle) on Knee	4
Marketed Dressing (Rectangle) on Knee	2
Prototype Dressing (Square) on Thigh	3
Marketed Dressing (Square) on Thigh	4
Prototype Dressing (Rectangle) on Knee	0
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0

Day 3: Border lift

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	20
Marketed Dressing (Rectangle) on Knee	40
Prototype Dressing (Square) on Thigh	32
Marketed Dressing (Square) on Thigh	41
Prototype Dressing (Rectangle) on Knee	100
Marketed Dressing (Rectangle) on Knee	82
Prototype Dressing (Square) on Thigh	90
Marketed Dressing (Square) on Thigh	79
Prototype Dressing (Rectangle) on Knee	4
Marketed Dressing (Rectangle) on Knee	3
Prototype Dressing (Square) on Thigh	1
Marketed Dressing (Square) on Thigh	1
Prototype Dressing (Rectangle) on Knee	0
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	1
Marketed Dressing (Square) on Thigh	0

Day 7: Border lift

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	7
Marketed Dressing (Rectangle) on Knee	17
Prototype Dressing (Square) on Thigh	3
Marketed Dressing (Square) on Thigh	11
Prototype Dressing (Rectangle) on Knee	107
Marketed Dressing (Rectangle) on Knee	103
Prototype Dressing (Square) on Thigh	106
Marketed Dressing (Square) on Thigh	102
Prototype Dressing (Rectangle) on Knee	5
Marketed Dressing (Rectangle) on Knee	4
Prototype Dressing (Square) on Thigh	6
Marketed Dressing (Square) on Thigh	4
Prototype Dressing (Rectangle) on Knee	2
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	5
Marketed Dressing (Square) on Thigh	1

Dressing Comfort Secondary · Day 1, Day 3 and Day 7

Dressing comfort measured by the count of participants at Day 1, 3 and 7 from the participant's answer to the question "was the dressing comfortable during wear?" from one of the following responses: 1. No 2. Yes 3. Dressing missing

Day 1: Was the dressing comfortable during wear?

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	6
Marketed Dressing (Rectangle) on Knee	4
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0
Prototype Dressing (Rectangle) on Knee	121
Marketed Dressing (Rectangle) on Knee	123
Prototype Dressing (Square) on Thigh	127
Marketed Dressing (Square) on Thigh	126
Prototype Dressing (Rectangle) on Knee	0
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	1

Day 3: Was the dressing comfortable during wear?

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	2
Marketed Dressing (Rectangle) on Knee	2
Prototype Dressing (Square) on Thigh	0
Marketed Dressing (Square) on Thigh	0
Prototype Dressing (Rectangle) on Knee	124
Marketed Dressing (Rectangle) on Knee	125
Prototype Dressing (Square) on Thigh	126
Marketed Dressing (Square) on Thigh	125
Prototype Dressing (Rectangle) on Knee	1
Marketed Dressing (Rectangle) on Knee	0
Prototype Dressing (Square) on Thigh	1
Marketed Dressing (Square) on Thigh	2

Day 7: Was the dressing comfortable during wear?

Group	Value	95% CI
Prototype Dressing (Rectangle) on Knee	5
Marketed Dressing (Rectangle) on Knee	3
Prototype Dressing (Square) on Thigh	2
Marketed Dressing (Square) on Thigh	1
Prototype Dressing (Rectangle) on Knee	119
Marketed Dressing (Rectangle) on Knee	122
Prototype Dressing (Square) on Thigh	120
Marketed Dressing (Square) on Thigh	120
Prototype Dressing (Rectangle) on Knee	3
Marketed Dressing (Rectangle) on Knee	2
Prototype Dressing (Square) on Thigh	5
Marketed Dressing (Square) on Thigh	6

Adverse events — posted to ClinicalTrials.gov

Time frame: Adverse events were collected upon dressing application on day 0 to dressing removal at day 7.. Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

All Participants: Systemic Events

Serious: 0/135 (0%)

Deaths: 0/135

Prototype Dressing (Rectangle) on Knee

Serious: 0/135 (0%)

Deaths: 0/135

Marketed Dressing (Rectangle) on Knee

Serious: 0/135 (0%)

Deaths: 0/135

Prototype Dressing (Square) on Thigh

Serious: 0/135 (0%)

Deaths: 0/135

Marketed Dressing (Square) on Thigh

Serious: 0/135 (0%)

Deaths: 0/135

Other adverse events (9 terms — click to expand)

Reaction	System	All Participants: Systemic…	Prototype Dressing (Rectan…	Marketed Dressing (Rectang…	Prototype Dressing (Square…	Marketed Dressing (Square)…
Pain	General disorders	—	—	—	—	—
Itching Sensation	Skin and subcutaneous tissue disorders	—	—	—	—	—
Headache	General disorders	—	—	—	—	—
Skin Inflammation/ Irritation	Skin and subcutaneous tissue disorders	—	—	—	—	—
Skin Discoloration	Skin and subcutaneous tissue disorders	—	—	—	—	—
Erythema	Skin and subcutaneous tissue disorders	—	—	—	—	—
Gastrointestinal Tract Infection	Gastrointestinal disorders	—	—	—	—	—
Period Cramps	Reproductive system and breast disorders	—	—	—	—	—
Fracture to little finger	Musculoskeletal and connective tissue disorders	—	—	—	—	—

Data from ClinicalTrials.gov NCT06700850 adverse events section.

Sponsor's own description

The purpose of this study is to evaluate two new prototype non-medicated multilayer foam dressings on healthy, intact skin. The study will find out how well two new prototype dressings stay in place as well as other dressing performance and safety factors when compared to corresponding, marketed dressings with a similar intended use profile and shape. The study will compare: 1. Prototype dressing (rectangle) vs Marketed dressing (rectangle) on the knee. 2. Prototype dressing (square) vs Marketed dressing (square) on the thigh. The main aim of the study is to show that the new prototype dressings are not worse than the established marketed comparison dressings in terms of staying in place on human participants at 7 days. Dressings will have successfully stayed in place if the dressing edges have not lifted to reach the pad, and the pad is not exposed in any way. Additional data will be collected to further support product performance up to 7 days, including safety information and potential device issues.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06700850 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Smith & Nephew, Inc.
Last refreshed: 2 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06700850.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing

NCT06700850

Quick facts

Drugs / interventions tested

Conditions studied

Sponsor

Who can join

Results — posted to ClinicalTrials.gov

Adverse events — posted to ClinicalTrials.gov

Sponsor's own description

Publications & conference data

Related trials

Other recruiting trials for Healthy

Other Smith & Nephew, Inc. trials

Verify against primary sources