NCT03238677

Treating Childhood Apraxia of Speech

Completed NA Results posted Last updated 22 June 2023

What this trial tests

NA trial testing Speech Motor Chaining without Biofeedback in Childhood Apraxia of Speech in 56 participants. Completed in 7 June 2022.

Timeline

1 August 2017

Primary endpoint
9 May 2022

7 June 2022

Quick facts

Lead sponsor	Syracuse University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	single
Primary purpose	treatment
Enrollment	56
Start date	1 August 2017
Primary completion	9 May 2022
Estimated completion	7 June 2022
Sites	1 location across United States

Drugs / interventions tested

• Speech Motor Chaining without Biofeedback
• Biofeedback
• Distributed Practice
• Massed --> Distributed Practice

Conditions studied

• Childhood Apraxia of Speech — all drugs for Childhood Apraxia of Speech →

Sponsor

Syracuse University

Who can join

Adults 9 to 17, any sex, with Childhood Apraxia of Speech. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Speech Sound Accuracy Primary · 10 weeks from the start of treatment

Percent consonants correct for target sounds: The primary outcome measure was percent correct for each participant's target sound-positions in untreated phrase. Participants imitated 20 pre-recorded phrases, each containing the target sound pattern 2 times per stimulus (e.g., for /l/ onset, "leave the location"), resulting in 40 attempts at each sound-position. For each session, 3 transcribers independently transcribed in Phon software (Hedlund \& Rose, 2022) and accuracy was averaged across transcribers. Instances where IPA symbols for the Actual transcription differed from the Target transcr

Group	Value	95% CI
Biofeedback, Massed->Distributed, Face-to-Face	54.1	± 13.5
No Biofeedback, Distributed, Face-to-Face	32.5	± 14.1
Biofeedback, Distributed, Face-to-Face	26.8	± 10.2
No Biofeedback, Massed-> Distributed, Face-to-Face	42.1	± 11.1
No Biofeeedback, Distributed, Telepractice	32.50	± 7.0
No Biofeedback, Massed->Distributed, Telepractice	43.0	± 7.7

Sponsor's own description

The study will test two modifications to speech therapy for 40 school-age children with childhood apraxia of speech to determine how to improve treatment outcomes. The study will compare treatment that includes real-time visual feedback of the tongue during speech using ultrasound vs traditional therapy that does not include ultrasound visual feedback. Additionally, some children will be treated with a traditional schedule of 2 sessions per week, whereas others will be provided with treatment that begins with intensive training (10 hours of therapy in one week) and progresses to a more distributed treatment schedule.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. A Randomized Controlled Trial of Treatment Distribution and Biofeedback Effects on Speech Production in School-Age Children With Apraxia of Speech.
   Preston JL, Caballero NF, Leece MC, Wang D, et al · · 2024 · cited 13× · PMID 37611182 · DOI 10.1044/2023_jslhr-22-00622