NCT05675306

Dose Frequency RCT on DTTC in Children With CAS

Active, enrolled NA Last updated 21 May 2025

What this trial tests

NA trial testing Dynamic Temporal and Tactile Cueing Treatment in Childhood Apraxia of Speech in 60 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 March 2023

Primary endpoint
30 November 2025

31 December 2025

Quick facts

Lead sponsor	Marquette University
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	60
Start date	1 March 2023
Primary completion	30 November 2025
Estimated completion	31 December 2025
Sites	1 location across United States

Drugs / interventions tested

• Dynamic Temporal and Tactile Cueing Treatment

Conditions studied

• Childhood Apraxia of Speech — all drugs for Childhood Apraxia of Speech →

Sponsor

Marquette University

Who can join

Adults 30 Months to 95, any sex, with Childhood Apraxia of Speech. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Childhood apraxia of speech (CAS) is a pediatric motor-based speech sound disorder that requires a specialized approach to intervention (Maas et al., 2014). The extant literature on the treatment of CAS commonly recommends intensive treatment using a motor-based approach, with some of the best evidence supporting the use of Dynamic Temporal and Tactile Cueing (DTTC; Strand, 2020). To date, a rigorous and systematic comparison of high and low dose frequency has not been undertaken for DTTC, resulting in a lack of evidence to guide decisions about the optimal treatment schedule for this intervention. The current study aims to fill this gap in knowledge by comparing treatment outcomes when dose frequency is varied.

The goal of this clinical trial is to determine whether the number of treatment sessions per week has an effect on intervention outcomes in 60 children with CAS. The main question this research will address is whether whole word accuracy will differ between two groups of children undergoing DTTC treatment when one group of children receives treatment twice a week for 12 weeks and the other group receives treatment 4 times a week for 6 weeks. Community clinicians will administer all treatment sessions.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Dose frequency randomized controlled trial for Dynamic Temporal and Tactile Cueing (DTTC) treatment for childhood apraxia of speech: protocol paper.
   Iuzzini-Seigel J, Case J, Grigos MI, Velleman SL, et al · · 2023 · cited 7× · PMID 37226208 · DOI 10.1186/s12887-023-04066-2
2. Dose frequency randomized control trial for Dynamic Temporal and Tactile Cueing (DTTC) treatment for childhood apraxia of speech: Protocol paper
   Iuzzini-Seigel J, Case J, Grigos M, Velleman S, et al · · 2023 · DOI 10.21203/rs.3.rs-2407181/v1