NCT03237689 (MsSCORE) is a EARLY_PHASE1 clinical trial of Hydrocortisone in Hiv, sponsored by Johns Hopkins University.

Who is sponsoring NCT03237689?

NCT03237689 is sponsored by Johns Hopkins University.

What drugs are being tested in NCT03237689?

Interventions in NCT03237689: Hydrocortisone, Placebo Oral Tablet.

Is NCT03237689 still recruiting?

NCT03237689 is currently completed. Last updated 29 September 2023.

Last reviewed 2023-09-29 · How we verify

NCT03237689: MsSCORE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Glucocorticoids on Cognition in HIV-infected Women

Completed EARLY_PHASE1 Last updated 29 September 2023

What this trial tests

EARLY_PHASE1 trial testing Hydrocortisone in Hiv in 136 participants. Completed in 8 September 2023.

Timeline

20 November 2017

Primary endpoint
8 September 2023

8 September 2023

Quick facts

Lead sponsor	Johns Hopkins University
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	basic science
Enrollment	136
Start date	20 November 2017
Primary completion	8 September 2023
Estimated completion	8 September 2023
Sites	1 location across United States

Drugs / interventions tested

Hydrocortisone (hydrocortisone) — full drug profile →
Placebo Oral Tablet — full drug profile →

Conditions studied

Hiv — all drugs for Hiv →

Sponsor

Johns Hopkins University

Who can join

Adults 18 to 65, female only, with Hiv. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Despite treatment with antiretroviral therapy, women living with HIV continue to experience cognitive impairment. Psychological risk factors, including stress, impair cognition more in HIV-infected women than HIV-uninfected women. This study plans to examine a novel intervention for cognitive dysfunction that targets the mechanisms by which stress negatively affects cognitive functioning.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Higher circulating intermediate monocytes are associated with cognitive function in women with HIV.
Veenhuis RT, Williams DW, Shirk EN, Abreu CM, et al · · 2021 · cited 33× · PMID 33914710 · DOI 10.1172/jci.insight.146215
A Systematic Review and Meta-Analysis of Social Cognition Among People Living with HIV: Implications for Non-Social Cognition and Social Everyday Functioning.
Vance DE, Billings R, Lambert CC, Fazeli PL, et al · · 2025 · cited 5× · PMID 38869661 · DOI 10.1007/s11065-024-09643-5

Verify or expand the search:

Other trials of Hydrocortisone

Trials testing the same drug.

NCT06381661 — Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Tra · Phase 2 · not yet recruiting
NCT06892210 — Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) · Phase 4 · recruiting
NCT07154849 — Comparative Study Between the Efficacy of Intravenous Hydrocortisone and Intravenous Dexmedetomidine for Prevention of P · Phase 4 · recruiting
NCT06515405 — Effect of Early Hydrocortisone on Risk of Gastrointestinal Perforations in Extremely Preterm Infants · active not recruiting
NCT06723626 — Effects of Intravenous Metabolic Recovery Agent in Elderly Septic Patients on Prognosis and Microcirculation. · NA · recruiting

Other recruiting trials for Hiv

Currently open trials in the same condition.

NCT06001814 — Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV · NA · recruiting
NCT06999928 — Enhanced Mentor Mother Strategy for Pregnant and Postpartum Women Living With HIV · NA · recruiting
NCT06006143 — Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2 · Phase 2 · active not recruiting
NCT07076043 — Multi-product PrEP Delivery to Young Women Seeking Reproductive Health Services and Coverage of HIV Prevention · Phase 4 · recruiting
NCT06389565 — Change My Story Task Shifted Mental Health Intervention · NA · recruiting

Other Johns Hopkins University trials

Trials by the same sponsor.

NCT06236542 — Tracheostomy Robotics and Cutting-edge Health Education for Airway Safety · NA · not yet recruiting
NCT07532252 — Daridorexant for Alcohol Use Disorder · Phase 2 · not yet recruiting
NCT06687655 — Impact of Exogenous Ketones on Sleep Apnea · Phase 1, PHASE2 · not yet recruiting
NCT07079111 — 3D Printed Occlusal Splints for Intraoperative Use · NA · not yet recruiting
NCT02998502 — The Use of a FDA Cleared, Drug-free, Breathing System for Anxiety and Panic Disorders in Children and Teens · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03237689 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
Last refreshed: 29 September 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03237689.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing