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NCT03215862
Lactated Ringer's Solution to Prevent Post-ERCP Pancreatitis
NA trial testing Lactated Ringer in Post-ERCP Acute Pancreatitis in 242 participants. Not yet recruiting.
1 August 2018
Quick facts
| Lead sponsor | University of South Florida |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 242 |
| Start date | 1 August 2017 |
| Primary completion | 1 August 2018 |
| Estimated completion | 1 August 2018 |
Drugs / interventions tested
- Lactated Ringer — full drug profile →
- Normal Saline 0.9% Infusion Solution Bag — full drug profile →
Conditions studied
- Post-ERCP Acute Pancreatitis — all drugs for Post-ERCP Acute Pancreatitis →
Sponsor
University of South Florida
Who can join
Adults 18 to 74, any sex, with Post-ERCP Acute Pancreatitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a randomized, double-blinded, controlled trial. This study is a head to head comparison of normal saline (NS) infusion versus Lactated Ringer's (LR) infusion in patients, with the primary outcome of post-ERCP pancreatitis occurrence. Patients will be randomized to either the NS infusion group or the LR infusion group. IVF will be started pre-procedurally and will be continued throughout the procedure. A IVF bolus will be given at the end of the procedure and then continued as a continuous infusion. Our null hypothesis is that there will be no significant difference in the rate of occurrence of post-ERCP pancreatitis between the infusion of LR and NS solutions. Our alternative hypothesis is that patients receiving LR solution infusion will experience a decreased rate of post-ERCP pancreatitis compared to patients receiving NS solution infusion.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Efficacy of aggressive hydration with normal saline versus lactated Ringer's solution for the prevention of post-ERCP pancreatitis in high-risk patients: a randomized controlled trial.
Patel R, Bertran-Rodriguez C, Kumar A, Brady P, et al · · 2022 · cited 5× · PMID 35845031 · DOI 10.1055/a-1834-6568
Verify or expand the search:
- PubMed search for NCT03215862
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Lactated Ringer
Trials testing the same drug.
- NCT05727969 — Dexmedetomidine Infusion and Surgical Pleth Index In Pediatrics · NA · completed
- NCT04732624 — Enteral Resuscitation Nepal (Pilot Study) · Phase 3 · completed
- NCT04102371 — Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis · Phase 3 · completed
- NCT04051580 — Comparison of Lactated Ringer's Solution and PlasmaLyte-A as a Base Solution for Del Nido Cardioplegia · NA · completed
- NCT03563378 — Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation · NA · unknown
Other recruiting trials for Post-ERCP Acute Pancreatitis
Currently open trials in the same condition.
- NCT07117318 — Rectal NSAIDs With/Without PD Stent for PEP Prevention · NA · recruiting
- NCT06260878 — Short-term Intravenous Fluids for Prevention of Post-ERCP Pancreatitis · Phase 4 · recruiting
- NCT05267379 — An European Multi-centre Cohort Study for Unravelling Pharmacokinetic and Genetic Factors Underlying Post-ERCP Pancreati · recruiting
Other University of South Florida trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03215862 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of South Florida
- Last refreshed: 12 July 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03215862.
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